| High-normal blood pressure is associated with a cluster of cardiovascular and metabolic risk factors: a population-based study. | |
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MedLine Citation:
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PMID: 19145777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A Few population-based studies have shown that high-normal blood pressure clusters with other cardiovascular risk factors. Increased inflammation, endothelial dysfunction, oxidative stress, and reduced adiponectin values have sporadically been reported in these patients. METHODS: We cross-sectionally compared blood pressure categories with cardiovascular risk factors in an adult population-based cohort (n = 1658) and evaluated the relationships between C-reactive-protein, nitrotyrosine, total antioxidant status, E-selectin, vascular adhesion molecule-1, intercellular adhesion molecule-1, resistin, adiponectin values and blood pressure categories in a subgroup of healthy lean individuals from this cohort (n = 107) in order to exclude the impact of obesity/insulin resistance on these variables. RESULTS: Glucose, triglyceride, low-density lipoprotein-cholesterol, alanine aminotranferase, gamma-glutamyl transferase values, and diabetes and metabolic syndrome prevalence were significantly higher in high-normal compared with the optimal blood pressure category. In the healthy subgroup, adiponectin (beta = - 4315.3; 95% confidence interval - 5916.4 -2654.2), total antioxidant status (-0.15; -0.3 -0.04) were significantly lower, and nitrotyrosine (1.2; 0.3 2.1), E-selectin (11.7; 1.8 21.6), vascular adhesion molecule-1 (0.3; 0.1 0.5), and intercellular adhesion molecule-1 (0.3; 0.1 0.5) were higher in high-normal compared with the optimal blood pressure category, at multiple regression analyses. CONCLUSIONS: Individuals with high-normal blood pressure had a higher prevalence of cardiovascular and metabolic risk factors than those with optimal, and, even if healthy, they showed reduced adiponectin values, early signs of endothelial dysfunction, and oxidative stress. Further research is needed to determine whether they will benefit from blood pressure reduction. |
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Authors:
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Simona Bo; Roberto Gambino; Luigi Gentile; Gianfranco Pagano; Rosalba Rosato; Giorgio Maria Saracco; Maurizio Cassader; Marilena Durazzo; Paolo Cavallo-Perin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 27 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 102-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Turin, Turin, Italy. sbo@molinette.piemonte.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Blood Pressure* Cardiovascular Diseases / etiology* Cholesterol, LDL / blood Cross-Sectional Studies Female Humans Hypertension / complications* Male Metabolic Syndrome X / etiology* Middle Aged Risk Factors gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2009 Jan;27(1):28-30
[PMID:
19050447
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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