Document Detail

High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men.
MedLine Citation:
PMID:  10867040     Owner:  NLM     Status:  MEDLINE    
Hydroxypropylmethylcellulose (HPMC) is a food gum that shares certain characteristics, such as high viscosity, with soluble fibers. In this trial, the safety and cholesterol-lowering efficacy of HPMC consumed with and between meals was evaluated in free-living male volunteers with mild-to-moderate hypercholesterolemia. After a 14-d baseline period, men (n = 51) with LDL cholesterol between 3.36 and 4.91 mmol/L and triglycerides <3.95 mmol/L were randomly assigned to consume 5.0 g/d HPMC in 240 mL of orange drink, taken either with or between meals, for a 2-wk treatment period. In the Between Meals group, total cholesterol was reduced by 8.0% vs. baseline in wk 1 of treatment (P < 0.05) and 5.1% in wk 2 (P < 0.01). LDL cholesterol concentrations fell by 12.0 and 7.7% (P < 0.01). In the With Meals group, reductions were 9.5 and 8.3% for total cholesterol, and 12.5 and 12.8% for LDL cholesterol (wk 1 and 2, respectively, P < 0.01). In both groups, HDL cholesterol decreased by approximately 5% during wk 1 of treatment (P < 0.01), but the wk 2 concentrations were not significantly different from baseline. There were no significant differences between groups in lipid responses, although there was a trend for a smaller LDL cholesterol-lowering effect during wk 2 of treatment in the Between Meals group (P < 0.06). Gastrointestinal-related adverse experiences (mostly mild) were twice as common among participants who ingested HPMC with meals (P < 0.05). These results suggest that HPMC has a lipid-lowering effect, which may be more consistent when taken with meals.
K C Maki; M H Davidson; S Torri; K A Ingram; J O'Mullane; B P Daggy; H H Albrecht
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1705-10     Citation Subset:  IM    
Chicago Center for Clinical Research, Chicago, IL, USA.
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MeSH Terms
Anticholesteremic Agents / administration & dosage,  adverse effects,  therapeutic use*
Body Weight / drug effects
Cholesterol / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Digestive System / drug effects
Feeding Behavior*
Hypercholesterolemia / drug therapy*
Lipids / blood
Methylcellulose / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Molecular Weight
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 57-88-5/Cholesterol; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose

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