| High-molecular-weight forms of somatostatin are reduced in Alzheimer's disease and Down's syndrome. | |
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MedLine Citation:
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PMID: 2869457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four molecular forms of somatostatin-like immunoreactivity (SOM-LI) are present in the human temporal cortex: SOM-14, SOM-28 and high-molecular-weight forms (HMW-SOM) of 7500 and 12,000 daltons. SOM-14 and HMW-SOM are depleted in cortical tissue from cases of pre-senile Alzheimer-type dementia (ATD), but there is a disproportionate reduction in HMW-SOM. In cases of Down's syndrome (DS) with the neuropathological and neurochemical changes of ATD, the total concentration of SOM-LI was similar to that in control cases and the proportions of molecular forms present were comparable. However, there was a significant reduction in the concentration of HMW-SOM. These results show that ATD and DS may share a common abnormality in the biosynthesis and/or post-translational processing of cortical SOM. |
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Authors:
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A R Pierotti; A J Harmar; J Simpson; C M Yates |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 63 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-04-03 Completed Date: 1986-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 141-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Alzheimer Disease / metabolism* Choline O-Acetyltransferase / metabolism Down Syndrome / metabolism* Female Humans Male Middle Aged Molecular Weight Peptides / analysis Somatostatin / analysis* Somatostatin-28 Temporal Lobe / analysis*, enzymology |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/somatostatin-like peptides; 51110-01-1/Somatostatin; 75037-27-3/Somatostatin-28; EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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