Document Detail


High-molecular-weight forms of somatostatin are reduced in Alzheimer's disease and Down's syndrome.
MedLine Citation:
PMID:  2869457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four molecular forms of somatostatin-like immunoreactivity (SOM-LI) are present in the human temporal cortex: SOM-14, SOM-28 and high-molecular-weight forms (HMW-SOM) of 7500 and 12,000 daltons. SOM-14 and HMW-SOM are depleted in cortical tissue from cases of pre-senile Alzheimer-type dementia (ATD), but there is a disproportionate reduction in HMW-SOM. In cases of Down's syndrome (DS) with the neuropathological and neurochemical changes of ATD, the total concentration of SOM-LI was similar to that in control cases and the proportions of molecular forms present were comparable. However, there was a significant reduction in the concentration of HMW-SOM. These results show that ATD and DS may share a common abnormality in the biosynthesis and/or post-translational processing of cortical SOM.
Authors:
A R Pierotti; A J Harmar; J Simpson; C M Yates
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  63     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-03     Completed Date:  1986-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Alzheimer Disease / metabolism*
Choline O-Acetyltransferase / metabolism
Down Syndrome / metabolism*
Female
Humans
Male
Middle Aged
Molecular Weight
Peptides / analysis
Somatostatin / analysis*
Somatostatin-28
Temporal Lobe / analysis*,  enzymology
Chemical
Reg. No./Substance:
0/Peptides; 0/somatostatin-like peptides; 51110-01-1/Somatostatin; 75037-27-3/Somatostatin-28; EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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