Document Detail


High microvessel density in primitive neuroectodermal brain tumors of childhood.
MedLine Citation:
PMID:  11414647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microvessel density (MVD), a measure of tumor angiogenesis, has been shown to correlate significantly with overall and progression-free survival outcomes in various cancers including astrocytic brain tumors. To assess if the MVD is an independent prognostic factor in primitive neuroectodermal tumors (PNET) of the central nervous system, formalin-fixed paraffin-embedded tumor sections of 78 children with PNET were studied by CD34 immunohistochemistry to highlight endothelial cells. Microvessel density was determined in the most active area of neovascularization according to well-established methods. While it was shown that MVD showed considerable inter-tumor variability (median 75; range 20-345 microvessels per 0.7 mm2 field), no significant associations were found between MVD and metastasis or survival outcomes. We conclude that many PNETs are highly vascular CNS tumors, indicating potent angiogenic activity. Therefore, these tumors would be good candidates for antiangiogenic strategies. However, MVD determined in the most active area of neovascularization is not a predictor of metastatic potential or survival outcomes in childhood PNET.
Authors:
M A Grotzer; R Wiewrodt; A J Janss; H Zhao; A Cnaan; L N Sutton; L B Rorke; P C Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropediatrics     Volume:  32     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-06-20     Completed Date:  2001-12-04     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
University Children's Hospital of Zurich, Switzerland. Michael.Grotzer@kispi.unizh.ch
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Neoplasms / blood supply*,  mortality,  pathology
Cell Division / physiology
Cerebellar Neoplasms / blood supply,  mortality,  pathology
Child
Child, Preschool
Female
Follow-Up Studies
Glial Fibrillary Acidic Protein / metabolism
Humans
Infant
Male
Medulloblastoma / blood supply,  mortality,  pathology
Microcirculation / pathology
Neovascularization, Pathologic / mortality,  pathology*
Neuroectodermal Tumors, Primitive / blood supply*,  mortality,  pathology
Survival Rate
Grant Support
ID/Acronym/Agency:
NS34514/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein

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