| High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension. | |
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MedLine Citation:
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PMID: 16915033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We evaluated maternal and fetal plasma levels and placental mRNA expression of urocortin, a placental vasoactive neuropeptide, in singleton pregnancies (n = 70) complicated by hypertensive disorders classified as gestational hypertension (n = 36), pre-eclampsia (n = 19), and pre-eclampsia complicated by intrauterine growth restriction (PE/IUGR, n = 15), and in 70 healthy normotensive singleton pregnancies. METHODS: Plasma levels were assayed by radioimmunoassay, fetal biometry by ultrasound scans, utero-placental and fetal perfusion by Doppler velocimetry, and placental urocortin mRNA expression by quantitative real time reverse transcriptase-polymerase chain reaction. The main outcome measures were the correlation of urocortin concentrations with patterns of the utero-placental and fetal circulation, and the early prediction of a poor neonatal outcome such as the occurrence of perinatal death and intraventricular hemorrhage. RESULTS: Maternal and fetal urocortin levels were significantly (both P < 0.001) higher in gestational hypertension, pre-eclampsia and PE/IUGR women than in controls, and correlated with Doppler velocimetry patterns. Fetal concentrations were significantly (P < 0.0001) higher than and significantly (P < 0.0001) correlated to maternal levels. Placental mRNA expression did not change. Ten out of 140 newborns had a poor neonatal outcome, with an overall prevalence of 7.14% (pretest probability). Using the receiver operator characteristics curve analysis cut-off values, the probability of a poor neonatal outcome was 66.7% when urocortin was used, and was 0% if levels were unaltered. CONCLUSIONS: Maternal and fetal urocortin levels are increased in hypertensive disorders of pregnancy. Since urocortin has vasoactive properties, the evidence of increased urocortin levels in hypertensive disorders may represent an adaptive fetal response. |
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Authors:
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Pasquale Florio; Michela Torricelli; Giulia De Falco; Eleonora Leucci; Alessia Giovannelli; Diego Gazzolo; Filiberto M Severi; Franco Bagnoli; Lorenzo Leoncini; Elizabeth A Linton; Felice Petraglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 24 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-17 Completed Date: 2007-01-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1831-40 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biometry Corticotropin-Releasing Hormone / biosynthesis, blood*, metabolism Female Fetal Growth Retardation / genetics Humans Hypertension, Pregnancy-Induced / blood* Placenta / metabolism Pre-Eclampsia / blood* Pregnancy Pregnancy Complications, Cardiovascular* RNA, Messenger / metabolism ROC Curve Radioimmunoassay Reverse Transcriptase Polymerase Chain Reaction Treatment Outcome Ultrasonography, Doppler Urocortins |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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