Document Detail


High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody.
MedLine Citation:
PMID:  16280707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Studies among HIV-1-infected women have demonstrated reduced placental transfer of IgG antibodies against measles and other pathogens. As a result, infants born to women with HIV-1 infection may not acquire adequate passive immunity in utero and this could contribute to high infant morbidity and mortality in this vulnerable population.
METHODS: To determine factors associated with decreased placental transfer of measles IgG, 55 HIV-1-infected pregnant women who were enrolled in a Nairobi perinatal HIV-1 transmission study were followed. Maternal CD4 count, HIV-1 viral load, and HIV-1-specific gp41 antibody concentrations were measured antenatally and at delivery. Measles IgG concentrations were assayed in maternal blood and infant cord blood obtained during delivery to calculate placental antibody transfer.
RESULTS: Among 40 women (73%) with positive measles titers, 30 (75%) were found to have abnormally low levels of maternofetal IgG transfer (<95%). High maternal HIV-1 viral load at 32 weeks' gestation and at delivery was associated with reductions in placental transfer (P < 0.0001 and P = 0.0056, respectively) and infant measles IgG concentrations in cord blood (P < 0.0001 and P = 0.0073, respectively). High maternal HIV-1-specific gp41 antibody titer was also highly correlated with both decreased placental transfer (P = 0.0080) and decreased infant IgG (P < 0.0001).
CONCLUSIONS: This is the first study to evaluate the relationship between maternal HIV-1 viremia, maternal HIV-1 antibody concentrations, and passive immunity among HIV-1-exposed infants. These data support the hypothesis that high HIV-1 viral load during the last trimester may impair maternofetal transfer of IgG and increases risk of measles and other serious infections among HIV-1-exposed infants.
Authors:
Carey Farquhar; Ruth Nduati; Nancy Haigwood; William Sutton; Dorothy Mbori-Ngacha; Barbra Richardson; Grace John-Stewart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  40     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-10     Completed Date:  2006-01-10     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-7     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood,  metabolism*
CD4 Lymphocyte Count
Female
HIV Antibodies / blood
HIV Infections / immunology*
Humans
Immunity, Maternally-Acquired*
Immunoglobulin G / blood,  metabolism*
Infant, Newborn
Measles / immunology*
Measles virus / immunology*
Pregnancy
Viral Load*
Grant Support
ID/Acronym/Agency:
D43 TW 00007/TW/FIC NIH HHS; D43 TW000007/TW/FIC NIH HHS; K23 HD 41879/HD/NICHD NIH HHS; K23 HD041879/HD/NICHD NIH HHS; K24 HD054314/HD/NICHD NIH HHS; P30 AI 27757/AI/NIAID NIH HHS; P30 AI027757/AI/NIAID NIH HHS; P30 AI027757-12/AI/NIAID NIH HHS; R01 HD 23412/HD/NICHD NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD023412-14/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/HIV Antibodies; 0/Immunoglobulin G
Comments/Corrections

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