Document Detail

High and low frequency electrical stimulation in non-lesional temporal lobe epilepsy.
MedLine Citation:
PMID:  17582791     Owner:  NLM     Status:  MEDLINE    
In patients with pharmacologically intractable epilepsy who are not eligible for surgery, deep brain stimulation is currently under evaluation as an alternative treatment. Optimal stimulation parameters, including high (HFS) versus low frequency (LFS) stimulation, are not well defined. Here, we report the effects of HFS (130 pulses per second, pps) and LFS (5pps) of the principal epileptogenic focus, in three patients with non-lesional temporal lobe epilepsy. HFS, but not LFS, was associated with a reduction of the interictal discharges and absence of seizures. HFS may be beneficial in patients with non-lesional temporal lobe epilepsy who are not surgical candidates.
Colette Boëx; Serge Vulliémoz; Laurent Spinelli; Claudio Pollo; Margitta Seeck
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-19
Journal Detail:
Title:  Seizure     Volume:  16     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-02-29     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  664-9     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Radiation
Electric Stimulation / methods*
Epilepsy, Temporal Lobe / therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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