| High lipoprotein (a) levels in chronic hemodialysis patients are closely related to the acute phase reaction. | |
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MedLine Citation:
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PMID: 8560404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the mechanism underlying the high lipoprotein (a) [Lp(a)] level in uremic patients on chronic hemodialysis, we investigated the levels of Lp(a), acute phase reactants (C-reactive protein and sialic acid), and interleukin-6 (IL-6) in 54 dialysis patients. The mean [95% CI] Lp(a) level was increased in the hemodialysis patients compared with the 30 controls (30 [25-36] vs. 18 [14-23] mg/dl, p < 0.005). Among dialysis patients, 46% had an Lp(a) level > 30 mg/dl, which was significantly higher than the percentage in the control group (17%). The levels of C-reactive protein, sialic acid, and IL-6 were also increased in dialysis subjects compared with controls (200 [134-299] vs. 37 [24-58] micrograms/dl, p < 0.0001; 63 [59-66] vs. 54 [52-56] mg/dl, p < 0.002; and 9.2 [7.8-11] vs. 5.5 [5.0-6.1] pg/ml, p < 0.0005, respectively). The Lp(a) level was positively correlated with that of C-reactive protein (r = 0.415, p < 0.002), sialic acid (r = 0.426, p < 0.002), and IL-6 (r = 0.298, p < 0.05) in the hemodialysis patients, but not in the controls or non-dialysis uremic patients. The Lp(a) level in the dialysis patients was also positively correlated with activation markers of coagulation (thrombin-antithrombin III complex and plasmin-alpha 2-plasmin inhibitor complex, p < 0.005). These results indicate that the Lp(a) level is closely related to the acute phase reaction and hypercoagulability in chronic hemodialysis patients. |
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Authors:
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K Kario; T Matsuo; H Kobayashi; M Matsuo; R Asada; M Koide |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 74 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-02-28 Completed Date: 1996-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1020-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Reaction
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blood*,
etiology Aged Biological Markers / blood* C-Reactive Protein / analysis Female Humans Interleukin-6 / blood* Lipoprotein(a) / blood* Male Middle Aged N-Acetylneuraminic Acid Renal Dialysis / adverse effects* Sialic Acids / blood Uremia / blood, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 0/Lipoprotein(a); 0/Sialic Acids; 131-48-6/N-Acetylneuraminic Acid; 9007-41-4/C-Reactive Protein |
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