Document Detail

High levels of serum uric acid are associated with silent brain infarction.
MedLine Citation:
PMID:  20674933     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Uric acid has been known to exert neuroprotective effects by acting as a free radical scavenger; however, several observational studies indicated that high levels of serum uric acid increased the risk of cardiovascular events or stroke. We sought to determine whether increased levels of uric acid are associated with the presence of silent brain infarction (SBI).
METHODS: We recruited a consecutive series of non-stroke individuals who visited the Healthcare System in our hospital and underwent brain MRI (n=1577). We conducted intensive interviews and laboratory examinations, including serum uric acid. We examined associations between SBI and vascular risk factors including uric acid by controlling possible confounders.
RESULTS: Of the 1577 subjects recruited, 921 were men and 656 were women, and the uric acid level was much higher in the men (6.3±1.3) than in the women (4.7±1.0). There was a strong dose-response relationship between the quartiles of uric acid and the presence of SBI in women (p=0.001), but not in men. Multivariable analysis showed that the highest quartile of uric acid level was an independent risk factor for the presence of SBI in total patients (adjusted OR, 1.79; 95% CI, 1.11-2.91). However, this association remained significant in women (adjusted OR, 2.64; 95% CI, 1.17-5.91), but not in men.
CONCLUSIONS: Our results suggest that an increased level of uric acid may be a risk factor for the presence of SBI. Serum uric acid level might be a good serum marker of underlying SBI or future stroke, especially in women.
Sung Hyuk Heo; Seung-Hoon Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-03
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  297     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Neurology, Kyunghee University College of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Analysis of Variance
Brain / pathology
Brain Infarction / blood*,  pathology
C-Reactive Protein / metabolism
Cardiovascular Diseases / blood*
Chi-Square Distribution
Magnetic Resonance Imaging / methods
Middle Aged
Risk Factors
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid; 9007-41-4/C-Reactive Protein

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