Document Detail


High levels of congenital transmission of Toxoplasma gondii in longitudinal and cross-sectional studies on sheep farms provides evidence of vertical transmission in ovine hosts.
MedLine Citation:
PMID:  15796013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent research suggests that vertical transmission may play an important role in sustaining Toxoplasma gondii infection in some species. We report here that congenital transmission occurs at consistently high levels in pedigree Charollais and outbred sheep flocks sampled over a 3-year period. Overall rates of transmission per pregnancy determined by PCR based diagnosis, were consistent over time in a commercial sheep flock (69%) and in sympatric (60%) and allopatric (41%) populations of Charollais sheep. The result of this was that 53.7 % of lambs were acquiring an infection prior to birth: 46.4% of live lambs and 90.0% of dead lambs (in agreement with the association made between T. gondii and abortion). No significant differences were observed between lamb sexes. Although we cannot distinguish between congenital transmission occurring due to primary infection at pregnancy or reactivation of chronic infection during pregnancy, our observations of consistently high levels of congenital transmission over successive lambings favour the latter.
Authors:
R H Williams; E K Morley; J M Hughes; P Duncanson; R S Terry; J E Smith; G Hide
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasitology     Volume:  130     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-30     Completed Date:  2005-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Affiliation:
Centre for Parasitology, Molecular Epidemiology and Ecology, Bioscience Research Institute, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Veterinary / parasitology*
Animals
Cross-Sectional Studies
Infectious Disease Transmission, Vertical / veterinary*
Longitudinal Studies
Sheep
Sheep Diseases / congenital*,  epidemiology*,  transmission
Toxoplasmosis, Animal / congenital*,  epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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