Document Detail


High levels of congenital transmission of Toxoplasma gondii in a commercial sheep flock.
MedLine Citation:
PMID:  11730799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our current understanding of congenital transmission of Toxoplasma gondii from ewe to lamb dictates that infection frequently results in abortion and the death of the developing foetus, that the birth of live infected lambs occurs rarely and that the cat is the predominant source of infection in ewes. Using direct polymerase chain reaction detection of T. gondii, we report high levels of congenital transmission occurring in a commercially managed sheep flock. We sampled foetal-derived placental tissue and tissues from aborted lambs and showed that congenital transmission was detected in these tissues from 61% of all pregnancies. Where pregnancies resulted in the death of one or more lambs, T. gondii was detected in the lamb tissue for all but one of 18 (94%) pregnancies. Of the successful pregnancies resulting in the birth of live lambs we were able to detect T. gondii in foetal-derived placental tissue from 37 of 70 (42%) pregnancies. These results show that congenital transmission is occurring in a high percentage of lambings including normal healthy lambings, at this farm, suggesting that this route of transmission from generation to generation may be much more significant than that reported previously. These results may have implications for sheep husbandry and future epidemiological studies of T. gondii.
Authors:
P Duncanson; R S Terry; J E Smith; G Hide
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for parasitology     Volume:  31     ISSN:  0020-7519     ISO Abbreviation:  Int. J. Parasitol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-03     Completed Date:  2002-05-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0314024     Medline TA:  Int J Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1699-703     Citation Subset:  IM    
Affiliation:
Centre for Molecular Epidemiology and Ecology, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
DNA, Protozoan / genetics
Female
Fetus / parasitology
Infectious Disease Transmission, Vertical / veterinary*
Placenta / parasitology
Polymerase Chain Reaction / veterinary
Pregnancy
Sheep
Sheep Diseases / parasitology,  transmission*
Toxoplasma / genetics*,  parasitology
Toxoplasmosis, Animal / congenital*
Toxoplasmosis, Congenital / parasitology,  transmission
Chemical
Reg. No./Substance:
0/DNA, Protozoan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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