Document Detail

High levels of Mn(2+) inhibit secretory pathway Ca(2+) /Mn(2+) -ATPase (SPCA) activity and cause Golgi fragmentation in neurons and glia.
MedLine Citation:
PMID:  22845487     Owner:  NLM     Status:  Publisher    
Excess Mn(2+) in humans causes a neurological disorder known as manganism, which shares symptoms with Parkinson's disease. However, the cellular mechanisms underlying Mn(2+) -neurotoxicity and the involvement of Mn(2+) -transporters in cellular homeostasis and repair are poorly understood and require further investigation. In the current work, we have analyzed the effect of Mn(2+) on neurons and glia from mice in primary cultures. Mn(2+) overload compromised survival of both cell types, specifically affecting cellular integrity and Golgi organization, where the Secretory Pathway Ca(2+) /Mn(2+) -ATPase (SPCA1) is localized. This ATP-driven Mn(2+) transporter might take part in Mn(2+) accumulation/detoxification at low loads of Mn(2+) , but its ATPase activity is inhibited at high concentration of Mn(2+) . Glial cells appear to be significantly more resistant to this toxicity than neurons and their presence in co-cultures provided some protection to neurons against degeneration induced by Mn(2+) . Interestingly, the Mn(2+) toxicity was partially reversed upon Mn(2+) removal by wash out or by the addition of EDTA as a chelating agent, in particular in glial cells. These studies provide data on Mn(2+) neurotoxicity and may contribute to explore new therapeutic approaches for reducing Mn(2+) poisoning. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
M Rosario Sepúlveda; Frank Wuytack; Ana M Mata
Related Documents :
11670187 - Unusual ring systems containing indium. synthesis and structure of the first mercuraind...
22590077 - (μ-4-bromo-3,5-dimethyl-pyrazolato-κ(2)n(1):n(2))-μ-chlorido-bis-[bis(4-bromo-3,5-di...
22589807 - Dichloridobis(2-phenyl-pyridine-κn)zinc(ii).
11196827 - Structural and photophysical studies of cu(nn)2+ systems in the solid state. emission a...
6272057 - Ubiquinones: stereochemistry and biological implications.
8649347 - Sparsomycin and its analogues: a new approach for evaluating their potency as inhibitor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain. Laboratory of Cellular Transport Systems, Department of Molecular Cell Biology, Faculty of Medicine, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies.
Next Document:  Atrial Bigeminy Results in Decreased Left Ventricular Function: An Insight into the Mechanism of PVC...