| High-level pyrantel resistance in the hookworm Ancylostoma caninum. | |
| | |
MedLine Citation:
|
PMID: 17011128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
While anthelmintic resistance is now a widely recognized issue in the livestock industries, its existence within companion animal medicine has been rarely established conclusively. We undertook a placebo-controlled in vivo trial to measure the efficacy of pyrantel embonate against pooled isolates of the hookworm Ancylostoma caninum from Brisbane, Australia. A statistically significant fall in adult worm burden was observed among dogs in the pyrantel treatment group compared to the control dogs (178.0+/-24.5 versus 239.7+/-14.0; p=0.02), equating to an efficacy of just 25.7% (95% CI, 15.0-35.1%), as based upon reduction in mean worm burden. Analysis of faecal egg count trends through the course of the study revealed that egg counts rose in both control and pyrantel-treated dogs, with a greater rise observed in the latter group (11.6+/-8.3% versus 17.3+/-7.6%; p=0.04), despite the decrease in adult worm numbers in this group. Our results indicate that high-level anthelmintic resistance does occur in companion animal medicine, and highlight the need for greater vigilance and more judicious use of anthelmintics in small animal practice. They further indicate that the faecal egg count reduction test needs to be used with caution with this parasite. |
| | |
Authors:
|
Steven R Kopp; Andrew C Kotze; James S McCarthy; Glen T Coleman |
Related Documents
:
|
8314968 - Pentoxifylline stimulates hyperactivation in human spermatozoa. 9771648 - In vitro and in vivo survival of frozen-thawed bovine oocytes after ivf, nuclear transf... 1932778 - Ecdysteroid synthesis and molting by the tobacco hornworm, manduca sexta, in the absenc... 17313508 - Impact of mosquito proofing of night shelters in refugee camps in kitgum, northern uganda. 8314968 - Pentoxifylline stimulates hyperactivation in human spermatozoa. 6830508 - Radial keratotomy. effect on cornea and aqueous humor physiology in the rabbit. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-29 |
Journal Detail:
|
Title: Veterinary parasitology Volume: 143 ISSN: 0304-4017 ISO Abbreviation: Vet. Parasitol. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-01-23 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7602745 Medline TA: Vet Parasitol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 299-304 Citation Subset: IM |
Affiliation:
|
School of Veterinary Science, University of Queensland, 4072 Qld, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Ancylostoma
/
drug effects* Ancylostomiasis / drug therapy, veterinary* Animals Antinematodal Agents / therapeutic use* Dog Diseases / drug therapy* Dogs Drug Resistance* Feces / parasitology Female Male Parasite Egg Count / veterinary Parasitic Sensitivity Tests / veterinary Pyrantel / therapeutic use* Random Allocation Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antinematodal Agents; 15686-83-6/Pyrantel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induce...
Next Document: Ecology of the free-living stages of major trichostrongylid parasites of sheep.