Document Detail

High-level pyrantel resistance in the hookworm Ancylostoma caninum.
MedLine Citation:
PMID:  17011128     Owner:  NLM     Status:  MEDLINE    
While anthelmintic resistance is now a widely recognized issue in the livestock industries, its existence within companion animal medicine has been rarely established conclusively. We undertook a placebo-controlled in vivo trial to measure the efficacy of pyrantel embonate against pooled isolates of the hookworm Ancylostoma caninum from Brisbane, Australia. A statistically significant fall in adult worm burden was observed among dogs in the pyrantel treatment group compared to the control dogs (178.0+/-24.5 versus 239.7+/-14.0; p=0.02), equating to an efficacy of just 25.7% (95% CI, 15.0-35.1%), as based upon reduction in mean worm burden. Analysis of faecal egg count trends through the course of the study revealed that egg counts rose in both control and pyrantel-treated dogs, with a greater rise observed in the latter group (11.6+/-8.3% versus 17.3+/-7.6%; p=0.04), despite the decrease in adult worm numbers in this group. Our results indicate that high-level anthelmintic resistance does occur in companion animal medicine, and highlight the need for greater vigilance and more judicious use of anthelmintics in small animal practice. They further indicate that the faecal egg count reduction test needs to be used with caution with this parasite.
Steven R Kopp; Andrew C Kotze; James S McCarthy; Glen T Coleman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-29
Journal Detail:
Title:  Veterinary parasitology     Volume:  143     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
School of Veterinary Science, University of Queensland, 4072 Qld, Australia.
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MeSH Terms
Ancylostoma / drug effects*
Ancylostomiasis / drug therapy,  veterinary*
Antinematodal Agents / therapeutic use*
Dog Diseases / drug therapy*
Drug Resistance*
Feces / parasitology
Parasite Egg Count / veterinary
Parasitic Sensitivity Tests / veterinary
Pyrantel / therapeutic use*
Random Allocation
Treatment Outcome
Reg. No./Substance:
0/Antinematodal Agents; 15686-83-6/Pyrantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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