| High level of expression of alpha-fetoprotein receptor in gastric cancers. | |
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MedLine Citation:
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PMID: 17028464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The expression of the receptor for alpha-fetoprotein (AFP-R) was examined immunohistochemically in 47 cancer and 14 benign human gastric tissues. Rabbit polyclonal antibody against human AFP-R was used for immunohistochemical staining. Thirty-four of the 47 cancer tissues expressed AFP-R showing granular or reticular staining on the cancer cell surface, while only 2 of 61 control cases (14 benign gastric tissues and 47 nonmalignant tissues adjacent to cancer) showed faint and homogeneous staining in the cytoplasm of noncancerous cells. There was a significant difference in staining intensity between the cancerous and noncancerous groups. However, no statistically significant difference in staining intensity was found among the groups of well-differentiated, moderately differentiated and poorly differentiated adenocarcinomas. On the other hand, the staining intensity of signet ring cell carcinoma was significantly weaker than that of the three adenocarcinoma groups. The high level of AFP-R expression in gastric cancers may allow the use of AFP-R as a new clinically useful marker of gastric cancer in the tissue level. |
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Authors:
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So Tsuboi; Kazuhisa Taketa; Kazuhiro Nouso; Tatsuya Fujikawa; Koji Manabe; Hiroyuki Ohmori; Toshihiro Higashi; Yasushi Shiratori |
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Publication Detail:
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Type: Journal Article Date: 2006-10-06 |
Journal Detail:
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Title: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Volume: 27 ISSN: 1010-4283 ISO Abbreviation: Tumour Biol. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-10-26 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8409922 Medline TA: Tumour Biol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 S. Karger AG, Basel. |
Affiliation:
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Department of Hepatology, Shigei Medical Research Hospital, 2117 Yamada, Okayama, Japan. tsuboi@shigei.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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metabolism,
pathology Gastritis / metabolism, pathology Humans Immunohistochemistry Kinetics Polyps / metabolism, pathology Receptors, Peptide / metabolism* Stomach Neoplasms / metabolism, pathology* Stomach Ulcer / metabolism, pathology alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Peptide; 0/alpha-Fetoproteins; 0/alpha-fetoprotein receptor, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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