| High level of c-fos mRNA accumulation is not obligatory for renewed cell proliferation. | |
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MedLine Citation:
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PMID: 3291868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the expression of the c-fos gene and the formation of inositol phosphates with respect to the reentry of inducible C2 myoblasts into the cell cycle. GI arrested myoblasts were stimulated to proliferate by addition of fresh medium containing either 20% foetal calf serum (FCS) or 1.6 10(-6) M insulin and 7 microM Na+ vanadate. Our results show that renewed proliferation, which occurred in the presence of insulin + vanadate, was neither preceded by increased inositol phosphate formation, nor by high level of c-fos mRNA accumulation, while, as classically observed, FCS induced proliferation was. These results suggest that increased inositol phospholipids breakdown and transient accumulation of c-fos mRNA at a high level, are not obligatory for renewed cell proliferation. |
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Authors:
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D Montarras; C Pinset; C Dubois; J Chenevert; F Gros |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 153 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-08-03 Completed Date: 1988-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1090-6 Citation Subset: IM |
Affiliation:
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Pasteur Institute, Department of Molecular Biology, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division* Gene Expression Regulation Inositol Phosphates / metabolism Insulin / pharmacology Mice Oncogenes* RNA, Messenger / metabolism* Vanadates / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Inositol Phosphates; 0/RNA, Messenger; 0/Vanadates; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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