| High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. | |
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MedLine Citation:
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PMID: 20459571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Neuroblastoma is a paediatric solid tumour with a poor outcome except in children <1 year old. Based on catecholamine urinary excretion, mass screening (MS) programmes have been organized but failed to decrease the mortality of this tumour. To test the hypotheses of a spontaneous maturation/differentiation or regression, the levels of poly (ADP-ribose) polymerase (PARP)-1, an early apoptosis marker, of PhosphoAKT, a major apoptosis inhibitor, and of maturation/differentiation were compared in standard and in MS neuroblastomas. METHODS AND RESULTS: We performed a case-control study of 55 primary tumours and 21 metastases of MS neuroblastomas. Matched controls were standard unscreened neuroblastomas and were paired according to age, stage, and MYCN amplification. The tumours were included in tissue microarrays. Immunohistochemical staining was performed using antibodies against, AKT, phosphoAKT, TRKB and PARP-1. The expression of PARP-1 and that of phosphoAKT were significantly higher in standard than in MS neuroblastomas independently of age and stage of the tumour. PhosphoAKT and PARP-1 expression was significantly correlated in both tumours. CONCLUSIONS: These data suggest that the better prognosis of patients with MS neuroblastomas compared with classical neuroblastomas was secondary to spontaneous tumour regression mediated by higher levels of apoptosis associated with low activation of AKT. |
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Authors:
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Hervé Sartelet; Shigeru Ohta; Stephane Barrette; Anne-Laure Rougemont; Marie Brevet; Marie Regairaz; Isabelle Harvey; Chantal Bernard; Monique Fabre; Louis Gaboury; Luc L Oligny; Jacques Bosq; Dominique Valteau-Couanet; Gilles Vassal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Histopathology Volume: 56 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 607-16 Citation Subset: IM |
Affiliation:
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Department of Pathology, CHU Sainte Justine Montreal, Montreal, Quebec, Canada. herve.sartelet.hsj@ssss.gouv.qc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Canada / epidemiology Case-Control Studies Child, Preschool Female Humans Infant Japan / epidemiology Kidney Neoplasms / epidemiology, metabolism, pathology* Male Mass Screening Mice Mice, Nude Neoplasm Staging Neuroblastoma / epidemiology, metabolism, secondary* Phosphorylation Poly(ADP-ribose) Polymerases / analysis, metabolism Proto-Oncogene Proteins c-akt / metabolism* Survival Rate Tissue Array Analysis Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; EC 2.4.2.30/PARP1 protein, human; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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