| High-intensity ultrasound treatment of blunt abdominal solid organ injury: an animal model. | |
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MedLine Citation:
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PMID: 15284566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: High-intensity focused ultrasound (HIFU) is effective in producing hemostasis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. METHOD: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 +/- 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. RESULTS: Organ hemostasis was achieved (mean +/- SD) with 15 +/- 6 minutes of HIFU treatment and 54 +/- 3 minutes of operating time, and 18.8 +/- 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 +/- 6.2 mL/kg abdominal serosanguinous fluid recovered. CONCLUSION: HIFU is effective in producing hemostasis by direct treatment of injured parenchyma in blunt trauma. |
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Authors:
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Carol J Cornejo; Shahram Vaezy; Gregory J Jurkovich; Marla Paun; Sam R Sharar; Roy W Martin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 57 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-30 Completed Date: 2004-08-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 152-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Harborview Medical Center, Univeristy of Washington, Seattle, Washington, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Injuries
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therapy* Animals Disease Models, Animal Hemorrhage / therapy* Hemostatic Techniques* Liver / injuries, pathology Swine Ultrasonic Therapy* Wounds, Nonpenetrating / therapy* |
| Grant Support | |
ID/Acronym/Agency:
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5R01-EB00292-03/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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