| High-intensity training improves airway responsiveness in inactive non-asthmatic children: evidence from a randomized controlled trial. | |
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MedLine Citation:
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PMID: 22241059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The relationship between physical activity and airway health in children is not well understood. The purpose of this study was to determine whether eight weeks of high-intensity exercise training would improve airway responsiveness in prepubescent, non-asthmatic, inactive children. METHODS: Sixteen healthy, prepubescent children were randomized (training group [TrG] n=8, control group [ConG] n=8). Prior to and following eight weeks of training (or no training), children completed pulmonary function tests (PFTs): forced expiratory volume in 1-sec (FEV(1)), forced vital capacity (FVC), forced expiratory flow at 25-75% of vital capacity (FEF(25-75)), and exhaled nitric oxide (eNO). Children completed an incremental cycle VO(2max) test, eucapnic voluntary hyperventilation (EVH), anthropometric tests, and blood tests to determine fasting blood glucose, total cholesterol, HDL, LDL, and triglycerides. Body fat percentage was determined using dual-energy x-ray absorptiometry pre-training and bioelectrical impedance pre- and post-training. RESULTS: There were no differences (p > 0.05) in anthropometric measures or PFTs between TrG and ConG at baseline. In the TrG, there was a significant increase in V0(2max) (~24%), a decrease in total cholesterol (~13%) and LDL cholesterol (~35%) following training. There were improvements (p < 0.05) in ΔFEV(1) both post-exercise (pre:-7.60 ± 2.10%, post:-1.10 ± 1.80%) and post-EVH (pre:-6.71 ± 2.21%, post:-1.41 ± 1.58%) with training. The ΔFEF(25-75) pre-post exercise also improved with training (pre:-16.10 ± 2.10%, post:-6.80 ± 1.80%; p < 0.05). Lower baseline body fat percentages were associated with greater improvements in pre-post exercise ΔFEV(1) following training (r = -0.80, p < 0.05). CONCLUSION: These results suggest that in non-asthmatic prepubescent children, inactivity negatively impacts airway responsiveness, which can be improved with high-intensity training. Excess adiposity, however, may constrain these improvements. |
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Authors:
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Sara K Rosenkranz; Richard R Rosenkranz; Tanis J Hastmann; Craig A Harms |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Western Sydney. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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