Document Detail


High-intensity training improves airway responsiveness in inactive nonasthmatic children: evidence from a randomized controlled trial.
MedLine Citation:
PMID:  22241059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: the relationship between physical activity and airway health in children is not well understood. The purpose of this study was to determine whether 8 wk of high-intensity exercise training would improve airway responsiveness in prepubescent, nonasthmatic, inactive children.
METHODS: 16 healthy, prepubescent children were randomized [training group (TrG) n = 8, control group (ConG) n = 8]. Prior to and following 8 wk of training (or no training), children completed pulmonary function tests (PFTs): forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), forced expiratory flow at 25-75% of vital capacity (FEF(25-75)), and exhaled nitric oxide (FENO). Children completed an incremental cycle Vo(2max) test, eucapnic voluntary hyperventilation (EVH), anthropometric tests, and blood tests to determine fasting blood glucose, total cholesterol, HDL, LDL, and triglycerides. Body fat percentage was determined using dual-energy X-ray absorptiometry pretraining and bioelectrical impedance pre- and posttraining.
RESULTS: there were no differences (P > 0.05) in anthropometric measures or PFTs between TrG and ConG at baseline. In the TrG, there was a significant increase in Vo(2max) (∼24%) and a decrease in total cholesterol (∼13%) and LDL cholesterol (∼35%) following training. There were improvements (P < 0.05) in ΔFEV(1) both postexercise (pre: -7.60 ± 2.10%, post: -1.10 ± 1.80%) and post-EVH (pre: -6.71 ± 2.21%, post: -1.41 ± 1.58%) with training. The ΔFEF(25-75) pre-post exercise also improved with training (pre: -16.10 ± 2.10%, post: -6.80 ± 1.80%; P < 0.05). Lower baseline body fat percentages were associated with greater improvements in pre-post exercise ΔFEV(1) following training (r = -0.80, P < 0.05).
CONCLUSION: these results suggest that in nonasthmatic prepubescent children, inactivity negatively impacts airway responsiveness, which can be improved with high-intensity training. Excess adiposity, however, may constrain these improvements.
Authors:
Sara K Rosenkranz; Richard R Rosenkranz; Tanis J Hastmann; Craig A Harms
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-01-12
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-07-26     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1174-83     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, Kansas State University, Manhattan, KS, USA. sararose@ksu.edu
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adipose Tissue / physiology
Adiposity / physiology
Airway Resistance / physiology*
Child
Data Interpretation, Statistical
Electric Impedance
Female
Forced Expiratory Flow Rates
Humans
Hyperventilation / physiopathology
Male
Motor Activity / physiology
Nitric Oxide / metabolism
Oxygen Consumption / physiology
Physical Fitness / physiology*
Respiratory Function Tests
Respiratory Muscles / physiology
Running / physiology
Vital Capacity / physiology
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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