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High intensity phototherapy for the treatment of severe non-hemolytic neonatal hyperbilirubinemia.
MedLine Citation:
PMID:  21251060     Owner:  NLM     Status:  Publisher    
Aim:  To describe the clinical approach to term and near-term newborn infants with severe hiperbilirubinemia and to analyse the effect of high intensity phototherapy on TSB levels. Methods:  We analysed a cohort of 116 newborn infants with severe non-hemolytic hyperbilirubinemia (TSB ≥ 20mg/dl / 342μmol/l). All patients were treated with high intensity phototherapy. The main outcomes were reduction of TSB levels in the first 24 hours of phototherapy, incidence of exchange transfusion, pathological brainstem auditory evoked responses and pathological findings on neurological examination at discharge. Results:  The mean birth weight and gestational age were 3161 ± 466g and 37.8 ± 1.6 weeks. Mean initial TSB concentration was 22.4 ± 2.4 mg/dl. Percent decrease in TSB after 2, 4, 6, 12, 18 and 24 hours of phototherapy were 9.4%, 16%, 23%, 40%, 44% and 50%, respectively. No infant was treated with exchange transfusion. BAER was performed in 100% of the patients and in 3 of them this exam was altered. However, when repeated 3 months later these BAER exams were normal. Neurological examination was normal in all patients. Conclusion:  High intensity phototherapy significantly reduces TSB in non-hemolytic severe hyperbilirubinemia and decreases the need for exchange transfusion.
Manoel de Carvalho; Christieny Chaipp Mochdece; Cynthia Amaral Moura Sá; Maria Elisabeth Lopes Moreira
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Foundation Acta Paediatrica.
Instituto Fernandes Figueira/Fiocruz Clinica Perinatal LaranjeirasInstituto Fernandes Figueira/FiocruzInstituto Fernandes Figueira/FiocruzInstituto Fernandes Figueira/Fiocruz Clinica Perinatal Laranjeiras Avenida Rui Barbosa 716 Flamengo- Rio de Janeiro- Brazil.
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