| High intensity knee extensor training restores skeletal muscle function in copd patients. | |
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MedLine Citation:
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PMID: 22408206 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Improving reduced skeletal muscle function is important for optimising exercise tolerance and quality of life in COPD patients. By applying high intensity training to a small muscle group, we hypothesised a normalization of muscle function.Seven patients with COPD performed six weeks (3 d·week(-1)) of high intensity interval aerobic knee extensor exercise training. Five age-matched healthy individuals served as reference group. Muscle oxygen uptake (VO2-peak) and mitochondrial respiration of the m.vastus lateralis were measured before and after the 6 week training program.Initial peak work and maximal mitochondrial respiration were reduced in COPD patients and improved significantly after the training program. Peak power and maximal mitochondrial respiration in m.vastus lateralis increased to control subjects' level and were mainly mediated via improved complex I respiration. Furthermore, when normalized to citrate synthase activity, no difference in maximal respiration was found neither after the intervention nor compared to controls, suggesting normal functioning mitochondrial complexes.The present study shows that high intensity training of a restricted muscle group is highly effective in restoring skeletal muscle function in COPD patients. |
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Authors:
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Eivind Brønstad; Oivind Rognmo; Arnt Erik Tjonna; Hans Henrich Dedichen; Idar Kirkeby-Garstad; Asta K Håberg; Charlotte Bjørk Ingul; Ulrik Wisløff; Sigurd Steinshamn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-9 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Norwegian University of Science and Technology, Trondheim, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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