Document Detail

High intensity focused ultrasound for the treatment of benign prostatic hyperplasia: early United States clinical experience.
MedLine Citation:
PMID:  7512658     Owner:  NLM     Status:  MEDLINE    
High intensity focused ultrasound via a transrectal approach was used to treat 15 patients with symptomatic benign prostatic hyperplasia. The first 10 of these 15 patients underwent continuous temperature monitoring of the periprostatic region throughout the treatment. Patients undergoing transperineal thermocouple placement for the purpose of thermometry were treated while under general or spinal anesthesia, whereas 4 of the 5 remaining patients were successfully treated using intravenous sedation alone. Of the 10 patients 9 did not demonstrate a significant temperature elevation. One patient with a small prostatic anteroposterior diameter had a transient elevation of 17C. No patient experienced a complication related to periprostatic heating. Followup was available at 90 days in all patients. At 90 days the symptom scores decreased from a pretreatment value (American Urological Association questions 1 to 7) of 31.2 (range 22 to 38) to 15.8 (range 8 to 31). Peak flow rate increased by a mean of 4.7 ml per second from 9.3 ml per second before treatment to 14.0 ml per second at 90 days. The most frequent complication was that of transient urinary retention in 11 of 15 patients (73.3%) and hematospermia in 7 (46.7%). No adverse reactions persisted at 90 days. This study represents an initial attempt using high intensity focused ultrasound to treat symptomatic benign prostatic hyperplasia. Overall, the safety and effectiveness of high intensity focused ultrasound demonstrated in this pilot study are encouraging.
R Bihrle; R S Foster; N T Sanghvi; J P Donohue; P J Hood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  151     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1271-5     Citation Subset:  AIM; IM    
Department of Urology, Indiana University Medical Center, Indianapolis.
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MeSH Terms
Aged, 80 and over
Magnetic Resonance Imaging
Middle Aged
Prostatic Hyperplasia / diagnosis,  therapy*,  ultrasonography
Ultrasonic Therapy* / adverse effects,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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