Document Detail

High-intensity focused ultrasound treatment of liver tumours: post-treatment MRI correlates well with intra-operative estimates of treatment volume.
MedLine Citation:
PMID:  22700259     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the safety and feasibility of high-intensity focused ultrasound (HIFU) ablation of liver tumours and to determine whether post-operative MRI correlates with intra-operative imaging.
METHODS: 31 patients were recruited into two ethically approved clinical trials (median age 64; mean BMI 26 kg m(-2)). Patients with liver tumours (primary or metastatic) underwent a single HIFU treatment monitored using intra-operative B-mode ultrasound. Follow-up consisted of radiology and histology (surgical trial) or radiology alone (radiology trial). Radiological follow-up was digital subtraction contrast-enhanced MRI.
RESULTS: Treatment according to protocol was possible in 30 of 31 patients. One treatment was abandoned because of equipment failure. Transient pain and superficial skin burns were seen in 81% (25/31) and 39% (12/31) of patients, respectively. One moderate skin burn occurred. One patient died prior to radiological follow-up. Radiological evidence of ablation was seen in 93% (27/29) of patients. Ablation accuracy was good in 89% (24/27) of patients. In three patients the zone of ablation lay ≤2 mm outside the tumour. The median cross-sectional area (CSA) of the zone of ablation was 5.0 and 5.1 cm(2) using intra-operative and post-operative imaging, respectively. The mean MRI:B-mode CSA ratio was 1.57 [95% confidence interval (CI)=0.57-2.71]. There was positive correlation between MRI and B-mode CSA (Spearman's r=0.48; 95% CI 0.11-0.73; p=0.011) and the slope of linear regression was significantly non-zero (1.23; 95% CI=0.68-1.77; p<0.0001).
CONCLUSIONS: HIFU ablation of liver tumours is safe and feasible. HIFU treatment is accurate, and intra-operative assessment of treatment provides an accurate measure of the zone of ablation and correlates well with MRI follow-up.
T Leslie; R Ritchie; R Illing; G Ter Haar; R Phillips; M Middleton; Bm Bch; F Wu; D Cranston
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-14
Journal Detail:
Title:  The British journal of radiology     Volume:  85     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-13     Completed Date:  2012-11-19     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1363-70     Citation Subset:  AIM; IM    
Oxford Clinical HIFU Unit, Churchill Hospital, Oxford, UK.
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MeSH Terms
Aged, 80 and over
Feasibility Studies
High-Intensity Focused Ultrasound Ablation / adverse effects,  methods*
Intraoperative Care / methods
Liver Neoplasms / pathology,  therapy*
Magnetic Resonance Imaging / methods
Middle Aged
Postoperative Care / methods
Prospective Studies
Treatment Outcome
Grant Support
//Cancer Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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