| High-intensity focused ultrasound to treat primary hyperparathyroidism: a feasibility study in four patients. | |
| | |
MedLine Citation:
|
PMID: 20858805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Many patients with primary hyperparathyroidism either decline or are not candidates for surgical parathyroidectomy. There are drawbacks to medical therapy as well as percutaneous ethanol injection as alternative therapies for primary hyperparathyroidism. Therefore, in this pilot study, our aim was to test the feasibility, safety, and efficacy of a newly developed noninvasive high-intensity focused ultrasound (HIFU) technique for the nonsurgical management of primary hyperparathyroidism. SUBJECTS AND METHODS: We treated four menopausal women with biochemical, sonographic, and cytologic evidence of benign primary hyperparathyroidism. HIFU treatment was performed in two sessions using TH-One under sonographic guidance and with the patient under conscious sedation. Parathyroid volume and function were evaluated at baseline and repeatedly until 12 months after the second HIFU session. RESULTS: Serum parathyroid hormone levels decreased in all four patients and normalized 1 and 8 months after the second HIFU session in two patients. Serum calcium levels decreased in all patients and normalized in three patients. Three of four parathyroid tumors had decreased in size by 11%, 43%, and 79%, respectively, 12 months after the second HIFU session. All adverse events related to HIFU were transient: mild subcutaneous edema in three patients and impaired vocal cord mobility in one patient that resolved 40 days later. CONCLUSION: HIFU is a promising procedure for patients with primary hyperparathyroidism that may become an alternative to established options, especially in elderly patients with comorbidities, or in patients who decline surgery. Large-scale long-term studies including patients with secondary and tertiary hyperparathyroidism are warranted. |
| | |
Authors:
|
Roussanka D Kovatcheva; Jordan D Vlahov; Alexander D Shinkov; Anna-Maria Borissova; Joo Ha Hwang; Françoise Arnaud; Laszlo Hegedüs |
Related Documents
:
|
19335765 - Vitamin d deficiency in children with haemophilia. 2795995 - Influence of 1 alpha-hydroxy vitamin d3 (0.25 micrograms/day) and calcium carbonate on ... 6835455 - Spontaneous remission of severe hyperparathyroidism in chronic renal failure. 19471295 - Vitamin a deficiency and other factors associated with severe tuberculosis in timor and... 17651165 - Serum lipoprotein (a) levels and behçet's disease: is there an association? 16682665 - Impact of metabolic syndrome on prognosis of symptomatic intracranial atherostenosis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: AJR. American journal of roentgenology Volume: 195 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-22 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
|
Languages: eng Pagination: 830-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Thyroid and Bone Mineral Diseases, Clinical Center of Endocrinology, Sofia Medical University, 1431 Sofia, Bulgaria. roussanka_kov@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Feasibility Studies Female High-Intensity Focused Ultrasound Ablation* / adverse effects Humans Hyperparathyroidism, Primary / therapy* Middle Aged Pilot Projects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prospective Study of Access Site Complications of Automated Contrast Injection With Peripheral Venou...
Next Document: PAVM Embolization: An Update.