Document Detail

High-intensity focused ultrasound in the treatment of postpartum hemorrhage: an animal model.
MedLine Citation:
PMID:  15027015     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the use of high-intensity focused ultrasound (HIFUS) to reduce uterine artery blood flow in ewes in the postpartum period. METHODS: HIFUS was applied to the uterine arteries of seven ewes in the postpartum period. Arterial flow velocities were measured before and after the procedure at the site of HIFUS application (target), as well as 3 cm upstream and 3 cm downstream from the target. The uterine arteries were then removed for macroscopic and histological examination. RESULTS: Maximum flow velocities in the target area increased after the procedure by 350% and those upstream from the target decreased by 65%. Macroscopically, the vessel diameter was shown to have reduced at the site of HIFUS application. Microscopically, both the endothelium and media showed thermal lesions. Tissues surrounding the arteries were macroscopically and microscopically normal. CONCLUSION: Exposure of uterine arteries to HIFUS reduces the vessel diameter and thus induces a dramatic increase in the maximum flow velocities within the target area. HIFUS may have a role in the treatment of postpartum hemorrhage.
J Nizard; M Pessel; B De Keersmaecker; J P Barbet; Y Ville
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  23     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-17     Completed Date:  2004-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  IM    
Copyright Information:
Copyright 2004 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, CHIPS, Poissy, France.
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MeSH Terms
Arteries / pathology,  physiopathology
Blood Flow Velocity
Disease Models, Animal
Postpartum Hemorrhage / therapy*
Postpartum Period / physiology
Regional Blood Flow
Ultrasonic Therapy / instrumentation,  methods*
Uterus / blood supply
Comment In:
Ultrasound Obstet Gynecol. 2004 Mar;23(3):216-7   [PMID:  15027006 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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