| High-intensity basal ganglia lesions on T1-weighted MR images in neurofibromatosis. | |
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MedLine Citation:
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PMID: 2512777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basal ganglia lesions, characterized on MR by increased signal intensity on T1-weighted images, were observed in seven patients with documented neurofibromatosis. These lesions most often involved the globus pallidus and internal capsules in a bilateral and symmetric fashion, and extended across the anterior commissure resulting in a "dumbbell" configuration. Smaller and less prominent foci of increased signal also were present on corresponding T2-weighted images. These lesions did not exhibit mass effect, edema, or enhancement with gadolinium-DTPA. They were not visible on CT (performed in two patients) and demonstrated no progression during a 2-year interval in three patients. Their signal characteristics and morphology suggest that they represent heterotopias containing Schwann cells and/or melanin deposits. Migrational abnormalities of these neural crest derivatives are known to occur in neurofibromatosis, and the presence of such heterotopias has been documented pathologically in patients with this disorder. While recent reports discuss foci of increased signal intensity on T2-weighted MR images in patients with neurofibromatosis, signal abnormalities on T1-weighted images have not yet been described. When lesions characterized by similar signal as well as morphologic characteristics are encountered on MR, the diagnosis of neurofibromatosis should be considered. |
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Authors:
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S A Mirowitz; K Sartor; M Gado |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 10 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1990-01-16 Completed Date: 1990-01-16 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1159-63 Citation Subset: IM |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Basal Ganglia / pathology*, radiography Child Child, Preschool Contrast Media Gadolinium DTPA Humans Magnetic Resonance Imaging* Neurofibromatosis 1 / diagnosis*, radiography Organometallic Compounds / diagnostic use Pentetic Acid / diagnostic use Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 67-43-6/Pentetic Acid; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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