Document Detail


High incorporation of L-amino acids to cereulide, an emetic toxin from Bacillus cereus.
MedLine Citation:
PMID:  10782675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cereulide is a principal toxin causing emetic syndrome produced by Bacillus cereus. This paper deals with biosynthetic studies on this unusual cyclic depsipeptide toxin from 13C labeled L-amino acid precursors (Val, Leu, Ala) upon cultivation in synthetic media. The analyses were made at atomic level of the constituent amino- or oxy-acids through NMR and ESI-MS/MS spectroscopic methods on cereulide and its hydrolysate dipeptides. The incorporation of the 13C atom was 95% in each O-Val, O-Leu and L-Val, while 40% in D-Ala of cereulide.
Authors:
M Kuse; T Franz; K Koga; S Suwan; M Isobe; N Agata; M Ohta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  10     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  IM    
Affiliation:
Laboratory of Organic Chemistry, School of Bioagricultural Sciences, Nagoya University, Chikusa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Bacillus subtilis / chemistry*
Bacterial Toxins / chemistry*
Depsipeptides*
Mass Spectrometry
Peptides, Cyclic / chemistry*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Bacterial Toxins; 0/Depsipeptides; 0/Peptides, Cyclic; 0/cereulide

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