| High incidence of radiation induced cavernous hemangioma in long-term survivors who underwent hematopoietic stem cell transplantation with radiation therapy during childhood or adolescence. | |
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MedLine Citation:
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PMID: 22198541 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Radiation induced cavernous hemangioma (RICH) is a late complication of cerebral radiation therapy. Long-term surviving hematopoietic stem cell transplant (HSCT) recipients who have received radiation therapy could be at risk of RICH. We investigated records for 68 patients who underwent HSCT during childhood or adolescence. Magnetic resonance (MR) imaging including T2*-weighted image of the brain was performed annually for 5 years, over a range of 6 to 29 years after HSCT. Furthermore, we developed a scoring and grading system for CH in order to monitor the process and the progress of radiological changes. Among the 68 patients, 28 (41.2%) were diagnosed as CH. All CH cases received total body irradiation as a conditioning treatment for HSCT and/or cranial radiation therapy prior to HSCT as part of the treatment for their primary disease. CH was found in none of those without radiation (N=19), in 46.2% of those who received 6-12 Gy (N=39) and in all of those who received 18-36 Gy (N=10). Total CH scores were correlated with higher radiation doses. Careful and long-term evaluation with MR imaging including T2*-weighted imaging is necessary for HSCT recipients who received radiation therapy prior to and/or during HSCT. |
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Authors:
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Takashi Koike; Noriharu Yanagimachi; Hiroyuki Ishiguro; Hiromasa Yabe; Miharu Yabe; Tsuyoshi Morimoto; Takashi Shimizu; Hiromitsu Takakura; Shunichi Kato |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
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Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: - ISSN: 1523-6536 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Tokai University School of Medicine; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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