| High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma. | |
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MedLine Citation:
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PMID: 12517817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In approximately 5% to 10% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas, evidence of Helicobacter pylori infection is absent, and their pathogenesis is poorly understood. We reviewed the clinical data and histology, and we examined t(11;18)(q21;q21) and BCL10 expression pattern in 17 such cases. In each case, the absence of H pylori was confirmed by negative serology and histology/immunohistochemistry. Five cases with stage I(E) disease were first treated with antibiotics, and none of them showed any endoscopic or histologic response. Review of the histology failed to identify any apparent difference between gastric MALT lymphomas with and without H pylori infection. Reverse transcription-polymerase chain reaction (RT-PCR) showed t(11;18)(q21;q21) in 9 (53%) of 17 cases, more frequent in lymphomas at stage II(E) or above (5 of 6) than those at stage I(E) (3 of 10). Two t(11;18)(q21;q21)-positive lymphomas were treated by partial gastrectomy and more than 16 years later showed lymphoma relapse in the gastric stump with dissemination to other mucosal sites, poorly responsive to therapy. BCL10 nuclear expression was observed in 7 of 8 t(11;18)(q21;q21)-positive cases and 4 of 7 t(11;18)(q21;q21)-negative cases, including one case suspicious for a BCL10-involved chromosomal translocation. Our results show that t(11;18)(q21;q21) occurs at a high frequency in H pylori-negative gastric MALT lymphomas. Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up. |
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Authors:
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Hongtao Ye; Hongxiang Liu; Markus Raderer; Andreas Chott; Agnes Ruskone-Fourmestraux; Andrew Wotherspoon; Martin J S Dyer; Shih-Sung Chuang; Ahmet Dogan; Peter G Isaacson; Ming-Qing Du |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-11-27 |
Journal Detail:
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Title: Blood Volume: 101 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-18 Completed Date: 2003-05-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 2547-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Histopathology, University College London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing* Adult Aged Carrier Proteins / analysis Cell Nucleus / chemistry Chromosomes, Human, Pair 11* Chromosomes, Human, Pair 18* Female Helicobacter pylori* / isolation & purification Humans Incidence Lymphoma, B-Cell, Marginal Zone / epidemiology, etiology, genetics* Male Middle Aged Neoplasm Staging Retrospective Studies Stomach Neoplasms / epidemiology, etiology, genetics* Translocation, Genetic* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Carrier Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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