Document Detail


High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma.
MedLine Citation:
PMID:  12517817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In approximately 5% to 10% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas, evidence of Helicobacter pylori infection is absent, and their pathogenesis is poorly understood. We reviewed the clinical data and histology, and we examined t(11;18)(q21;q21) and BCL10 expression pattern in 17 such cases. In each case, the absence of H pylori was confirmed by negative serology and histology/immunohistochemistry. Five cases with stage I(E) disease were first treated with antibiotics, and none of them showed any endoscopic or histologic response. Review of the histology failed to identify any apparent difference between gastric MALT lymphomas with and without H pylori infection. Reverse transcription-polymerase chain reaction (RT-PCR) showed t(11;18)(q21;q21) in 9 (53%) of 17 cases, more frequent in lymphomas at stage II(E) or above (5 of 6) than those at stage I(E) (3 of 10). Two t(11;18)(q21;q21)-positive lymphomas were treated by partial gastrectomy and more than 16 years later showed lymphoma relapse in the gastric stump with dissemination to other mucosal sites, poorly responsive to therapy. BCL10 nuclear expression was observed in 7 of 8 t(11;18)(q21;q21)-positive cases and 4 of 7 t(11;18)(q21;q21)-negative cases, including one case suspicious for a BCL10-involved chromosomal translocation. Our results show that t(11;18)(q21;q21) occurs at a high frequency in H pylori-negative gastric MALT lymphomas. Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up.
Authors:
Hongtao Ye; Hongxiang Liu; Markus Raderer; Andreas Chott; Agnes Ruskone-Fourmestraux; Andrew Wotherspoon; Martin J S Dyer; Shih-Sung Chuang; Ahmet Dogan; Peter G Isaacson; Ming-Qing Du
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-11-27
Journal Detail:
Title:  Blood     Volume:  101     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-18     Completed Date:  2003-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2547-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Histopathology, University College London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing*
Adult
Aged
Carrier Proteins / analysis
Cell Nucleus / chemistry
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 18*
Female
Helicobacter pylori* / isolation & purification
Humans
Incidence
Lymphoma, B-Cell, Marginal Zone / epidemiology,  etiology,  genetics*
Male
Middle Aged
Neoplasm Staging
Retrospective Studies
Stomach Neoplasms / epidemiology,  etiology,  genetics*
Translocation, Genetic*
Treatment Failure
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Carrier Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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