Document Detail

High incidence of hearing loss in long-term survivors of multisystem Langerhans cell histiocytosis.
MedLine Citation:
PMID:  19813249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ear involvement in the acute phase of Langerhans cell histiocytosis (LCH) is commonly seen and well documented, but the long-term sequelae are less well described, particularly in relation to hearing loss. METHODS: We investigated 40 patients with biopsy-proven multisystem LCH >5 years from the end of treatment, using detailed audiological assessment and CT/MRI imaging of the petrous temporal bones. RESULTS: The incidence of ear involvement in the acute phase of disease was 70%. Fifteen of the 39 patients tested (38%) had residual permanent hearing loss at long-term follow-up. CONCLUSIONS: The incidence of hearing loss is much higher than has previously been reported in LCH, and may reflect a referral bias of young (<2 years) and more complex patients to our tertiary centre. However, the hearing loss appears to be highly specific to this patient group when compared to other long-term survivors of childhood cancers, probably due to the propensity of LCH to involve the ears. We therefore recommend audiology testing as an important part of long-term follow-up for patients with multisystem LCH.
Vasanta Nanduri; Ruth Tatevossian; Tony Sirimanna
Related Documents :
23455629 - A large prospective european cohort study of patients treated with strontium ranelate a...
23676149 - The perihematomal glutamate level is associated with the outcome of patients with basal...
24029429 - Individualized anemia management reduces hemoglobin variability in hemodialysis patients.
24842909 - Antiretroviral therapy and efficacy after virologic failure on first-line boosted prote...
24495319 - Evaluation of chest tube administration of tissue plasminogen activator to treat retain...
23833529 - Effect of mifepristone (25 mg) in treatment of uterine myoma in perimenopausal woman.
20622749 - Hemivertebra resection for congenital scoliosis in young children: comparison of clinic...
7375889 - Late thrombotic malfunction of the björk-shiley tilting disc valve in the tricuspid pos...
9732919 - Reversal of fundic atrophy after eradication of helicobacter pylori.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  54     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  449-53     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
Department of Paediatrics, Watford General Hospital, Watford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Cohort Studies
Follow-Up Studies
Hearing Loss / etiology*
Histiocytosis, Langerhans-Cell / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Quid Pro Quo of pediatric versus adult services for older adolescent cancer patients.
Next Document:  Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Associ...