| High incidence of free monoclonal lambda light chains in the sera of patients with Sjogren's syndrome. | |
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MedLine Citation:
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PMID: 6406594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sjogren's syndrome presents a wide spectrum of disease manifestations ranging from benign to malignant lymphoproliferation. Sera from 21 patients with primary Sjogren's syndrome, 63 patients with other autoimmune rheumatic diseases, and 140 normal controls were studied by using high-resolution gel electrophoresis combined with immunofixation and specific absorption studies. Two-thirds of the sera from Sjogren's syndrome patients contained free monoclonal lambda light chains. In addition, one patient with Sjogren's syndrome and pseudolymphoma had a circulating monoclonal IgM-lambda immunoglobulin. In contrast, only 16% of the patients with other autoimmune diseases and 5% of normals had monoclonal bands; none of the other patients studied exhibited monoclonal-free lambda light chains in their serum. Our findings suggest that the monoclonal process in Sjogren's syndrome starts early in the disease process in a subset of B cells. |
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Authors:
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H M Moutsopoulos; A D Steinberg; A S Fauci; H C Lane; N M Papadopoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 130 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1983 Jun |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2663-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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analysis* Arthritis, Rheumatoid / complications, immunology Autoimmune Diseases / complications, immunology* Humans Immunoglobulin Light Chains / analysis* Immunoglobulin lambda-Chains / analysis* Lupus Erythematosus, Systemic / complications, immunology Sjogren's Syndrome / complications, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin Light Chains; 0/Immunoglobulin lambda-Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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