| High incidence of false-positive Aspergillus galactomannan test in multiple myeloma. | |
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MedLine Citation:
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PMID: 20513124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Invasive aspergillosis (IA) remains one of the most significant causes of morbidity and mortality in patients with hematological malignancies undergoing chemotherapy and hematopoietic stem cell transplantation (HSCT), mainly due to the difficulty in its early diagnosis. Monitoring of galactomannan (GM) antigen, an exoantigen of Aspergillus, in the blood by sandwich ELISA is a useful and noninvasive method for early diagnosis of IA. The GM test has a sensitivity of 67-100% with a specificity of 81-99% in neutropenic patients and allogeneic transplant recipients [1-3]. Although it has been widely used as a diagnostic criterion for IA [4,5], one of the major limitations of this assay is false-positivity, particularly in pediatric patients [1], patients with graft-versus-host disease (GVHD) [6,7], and those taking dietary GM [8,9] or fungus-derived antibiotics, such as piperacillin-tazobactam (PIPC/TAZ) [10-12]. |
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Authors:
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Yasuo Mori; Yoji Nagasaki; Kenjiro Kamezaki; Katsuto Takenaka; Hiromi Iwasaki; Naoki Harada; Toshihiro Miyamoto; Yasunobu Abe; Nobuyuki Shimono; Koichi Akashi; Takanori Teshima |
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Publication Detail:
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Type: Letter |
Journal Detail:
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Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 449-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amoxicillin
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pharmacology,
therapeutic use Antibiotic Prophylaxis Antigens, Fungal / blood* Artifacts Aspergillosis / blood, diagnosis* Aspergillus / chemistry*, immunology, isolation & purification False Positive Reactions Hematologic Diseases / blood* Hematologic Neoplasms / blood Humans Immunoglobulin G / blood Mannans / blood* Multiple Myeloma / blood*, drug therapy Myeloma Proteins / analysis Penicillanic Acid / analogs & derivatives, pharmacology, therapeutic use Piperacillin / pharmacology, therapeutic use Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Fungal; 0/Immunoglobulin G; 0/Mannans; 0/Myeloma Proteins; 11078-30-1/galactomannan; 157044-21-8/piperacillin-tazobactam combination product; 26787-78-0/Amoxicillin; 61477-96-1/Piperacillin; 87-53-6/Penicillanic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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