Document Detail

High incidence of bronchospasm with regular administration of aerosolized pentamidine.
MedLine Citation:
PMID:  1729115     Owner:  NLM     Status:  MEDLINE    
A systematic evaluation of changes in pulmonary status by objective spirometric assessment and subjective rating using visual analog scale was performed in a cohort of 134 patients receiving aerosolized pentamidine (AP) for the prevention of Pneumocystis carinii pneumonia. Significant bronchospasm defined as greater than or equal to 15 percent reduction in the forced expiratory volume in 1 s was noted in 26 of 100 (26 percent) of patients receiving AP alone. Despite the use of salbutamol (albuterol) as concurrent aerosolized treatment in 34 subjects, bronchospasm developed in 9 of 34 (26 percent) of the patients. The subjective respiratory status rating scale was found to be unreliable in correctly predicting the development of bronchospasm. We conclude that a high incidence of bronchospasm is present in patients receiving regular AP administration using an ultrasonic nebulizer as studied, and concurrent administration of salbutamol is not fully protective of this acute adverse pulmonary reaction.
M Katzman; W Meade; K Iglar; A Rachlis; P Berger; C K Chan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  101     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-11     Completed Date:  1992-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-81     Citation Subset:  AIM; IM; X    
Department of Medicine, Wellesley Hospital, Sunnybrook Medical Center, Canada.
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MeSH Terms
Albuterol / administration & dosage
Bronchial Spasm / chemically induced*,  physiopathology,  prevention & control
Forced Expiratory Volume
HIV Infections / complications
Pentamidine / administration & dosage,  adverse effects*
Pneumonia, Pneumocystis / complications,  prevention & control
Prospective Studies
Reg. No./Substance:
0/Aerosols; 100-33-4/Pentamidine; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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