| High incidence of bronchospasm with regular administration of aerosolized pentamidine. | |
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MedLine Citation:
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PMID: 1729115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A systematic evaluation of changes in pulmonary status by objective spirometric assessment and subjective rating using visual analog scale was performed in a cohort of 134 patients receiving aerosolized pentamidine (AP) for the prevention of Pneumocystis carinii pneumonia. Significant bronchospasm defined as greater than or equal to 15 percent reduction in the forced expiratory volume in 1 s was noted in 26 of 100 (26 percent) of patients receiving AP alone. Despite the use of salbutamol (albuterol) as concurrent aerosolized treatment in 34 subjects, bronchospasm developed in 9 of 34 (26 percent) of the patients. The subjective respiratory status rating scale was found to be unreliable in correctly predicting the development of bronchospasm. We conclude that a high incidence of bronchospasm is present in patients receiving regular AP administration using an ultrasonic nebulizer as studied, and concurrent administration of salbutamol is not fully protective of this acute adverse pulmonary reaction. |
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Authors:
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M Katzman; W Meade; K Iglar; A Rachlis; P Berger; C K Chan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 101 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-11 Completed Date: 1992-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 79-81 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Medicine, Wellesley Hospital, Sunnybrook Medical Center, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Albuterol / administration & dosage Bronchial Spasm / chemically induced*, physiopathology, prevention & control Forced Expiratory Volume HIV Infections / complications Humans Pentamidine / administration & dosage, adverse effects* Pneumonia, Pneumocystis / complications, prevention & control Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 100-33-4/Pentamidine; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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