| High incidence of arterial thrombosis in young patients treated for multiple myeloma: results of a prospective cohort study. | |
| | |
MedLine Citation:
|
PMID: 20339094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This prospective study evaluated the risk of arterial thrombosis in 195 consecutive patients aged 18 to 65 years with newly diagnosed multiple myeloma (MM). All patients were treated with 3 cycles of VAD (vincristine, doxorubicin, and dexamethasone) or TAD (thalidomide-AD) or PAD (bortezomib-AD) in national trials, followed by high-dose melphalan and autologous stem cell transplantation. For a period of 522 patient-years, 11 of the 195 patients (5.6%) developed arterial thrombosis. The highest incidence was seen during induction chemotherapy courses. Median age at onset of arterial thrombosis was 59 years (range, 43-65 years). Hypertension and smoking were significantly associated with arterial thrombosis with a relative risk of 11.7 (2.23-61.2) and 15.2 (1.78-130), respectively. Factor VIII levels (FVIII:C) correlated significantly with age (P = .02) and higher International Scoring System (ISS) stage (P = .001). A higher FVIII:C was associated with arterial thrombosis (hazard ratio [HR] = 1.85; 95% confidence interval [CI] = 0.99-3.47) after adjustment for age, ISS score, and assigned treatment arm. MM patients have an increased risk for arterial thrombotic events during and after induction chemotherapy. Hypertension, smoking, and high factor VIII levels, possibly reflecting disease activity, contribute to the risk of arterial thrombosis. |
| | |
Authors:
|
Eduard J Libourel; Pieter Sonneveld; Bronno van der Holt; Moniek P M de Maat; Frank W G Leebeek |
Related Documents
:
|
8643214 - Homocysteine--an atherogenic and a thrombogenic factor? 11769154 - Popliteal artery thrombosis secondary to exostosis of the tibia. 11499754 - Expression of exogenous tissue factor pathway inhibitor in vivo suppresses thrombus for... 16258304 - Thrombotic effect of purposeful back-wall stitch for different suture locations and ves... 21822984 - De novo basilar artery aneurysm formation after placement of a wingspan stent. 3215324 - Popliteal venous aneurysm. |
Publication Detail:
|
Type: Journal Article Date: 2010-03-25 |
Journal Detail:
|
Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-09 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
|
Languages: eng Pagination: 22-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Hematology, Erasmus University Medical Centre, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Boronic Acids / administration & dosage Clinical Trials, Phase III as Topic Dexamethasone / administration & dosage Doxorubicin / administration & dosage Female Humans Incidence Male Middle Aged Multiple Myeloma / complications*, drug therapy* Multivariate Analysis Outcome Assessment (Health Care) / statistics & numerical data Proportional Hazards Models Prospective Studies Pyrazines / administration & dosage Randomized Controlled Trials as Topic Risk Assessment / statistics & numerical data Risk Factors Thalidomide / administration & dosage Thrombosis / epidemiology, etiology* Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-35-1/Thalidomide; 57-22-7/Vincristine |
| Comments/Corrections | |
Comment In:
|
Blood. 2010 Jul 8;116(1):2-3
[PMID:
20616223
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Downregulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell ...
Next Document: Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human ...