Document Detail

High incidence of ankle arthropathy in mild and moderate haemophilia A.
MedLine Citation:
PMID:  21057696     Owner:  NLM     Status:  MEDLINE    
A clinical study of patients with mild haemophilia A to document the frequency and severity of arthropathy has not been previously published. We studied ankle arthropathy in 34 patients with mild/moderate haemophilia A. The patients were assessed for the presence and severity of pain, and by the physical and radiological scoring systems for the evaluation of haemophilic arthropathy recommended by the World Federation of Haemophilia (WFH). Of the 34 patients, 16 (47%) had ankle pain, which was of moderate to severe degree in nine patients, and associated with limitation of physical activities in 13 patients. Of 33 patients examined by radiology 17 (52%) were positive for ankle arthropathy, and of these, 16 were also positive by the physical score. The presence and severity of ankle arthropathy was more common in patients with a one-stage factor VIII level of less than or equal to 11 IU/dl. There was a significant relationship between the presence of ankle arthropathy and a history of bleeds into the ankle joint as a child. We conclude that arthropathy of the ankle in these patients is common, is often severe and disabling, and is due to episodes of bleeding into the ankle joint during childhood.
Min Ling; Jonathan Peter Hans Heysen; Elizabeth Mary Duncan; Susan Elizabeth Rodgers; John Viner Lloyd
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Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  105     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-05-31     Revised Date:  2012-01-10    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.
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MeSH Terms
Age Factors
Ankle Joint* / physiopathology,  radiography
Arthralgia / epidemiology,  etiology
Arthrometry, Articular
Biological Markers / blood
Factor VIII / analysis
Hemarthrosis / epidemiology,  etiology
Hemophilia A / blood,  complications*,  epidemiology
Joint Diseases / diagnosis,  epidemiology,  etiology*
Joint Instability / epidemiology,  etiology
Middle Aged
Pain Measurement
Range of Motion, Articular
Risk Assessment
Risk Factors
Severity of Illness Index
South Australia / epidemiology
Young Adult
Reg. No./Substance:
0/Biological Markers; 9001-27-8/Factor VIII

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