| High incidence of ankle arthropathy in mild and moderate haemophilia A. | |
| | |
MedLine Citation:
|
PMID: 21057696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A clinical study of patients with mild haemophilia A to document the frequency and severity of arthropathy has not been previously published. We studied ankle arthropathy in 34 patients with mild/moderate haemophilia A. The patients were assessed for the presence and severity of pain, and by the physical and radiological scoring systems for the evaluation of haemophilic arthropathy recommended by the World Federation of Haemophilia (WFH). Of the 34 patients, 16 (47%) had ankle pain, which was of moderate to severe degree in nine patients, and associated with limitation of physical activities in 13 patients. Of 33 patients examined by radiology 17 (52%) were positive for ankle arthropathy, and of these, 16 were also positive by the physical score. The presence and severity of ankle arthropathy was more common in patients with a one-stage factor VIII level of less than or equal to 11 IU/dl. There was a significant relationship between the presence of ankle arthropathy and a history of bleeds into the ankle joint as a child. We conclude that arthropathy of the ankle in these patients is common, is often severe and disabling, and is due to episodes of bleeding into the ankle joint during childhood. |
| | |
Authors:
|
Min Ling; Jonathan Peter Hans Heysen; Elizabeth Mary Duncan; Susan Elizabeth Rodgers; John Viner Lloyd |
Related Documents
:
|
3180576 - Two-stage reimplantation in infected total knee arthroplasty. 479236 - Joint replacement in non-ambulatory patients. 19411396 - Effect of musculoskeletal pain on sexuality of male adolescents and adults with juvenil... 509826 - Effect of tourniquet time on postoperative quadriceps function. 6109866 - Hypercalcaemia in hospital patients. clinical and diagnostic aspects. 16387906 - Pediatric enteral nutrition. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-05 |
Journal Detail:
|
Title: Thrombosis and haemostasis Volume: 105 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-02 Completed Date: 2011-05-31 Revised Date: 2012-01-10 |
Medline Journal Info:
|
Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
|
Languages: eng Pagination: 261-8 Citation Subset: IM |
Affiliation:
|
Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Ankle Joint* / physiopathology, radiography Arthralgia / epidemiology, etiology Arthrometry, Articular Biological Markers / blood Factor VIII / analysis Hemarthrosis / epidemiology, etiology Hemophilia A / blood, complications*, epidemiology Humans Incidence Joint Diseases / diagnosis, epidemiology, etiology* Joint Instability / epidemiology, etiology Middle Aged Pain Measurement Prevalence Range of Motion, Articular Registries Risk Assessment Risk Factors Severity of Illness Index South Australia / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fibrin presence within aortic valves in patients with aortic stenosis: association with in vivo thro...
Next Document: Effects of aspirin and desmopressin on platelet reactivity in patients undergoing cardiac surgery wi...