| High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm. | |
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MedLine Citation:
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PMID: 9128808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 287 base pair insertion/deletion polymorphism in intron 16 of the angiotensin I converting enzyme (ACE) gene was examined by polymerase chain reaction in 36 Kawasaki disease patients (16 without coronary aneurysm, 20 with coronary aneurysm). A polymorphism in the ACE gene was characterized by three genotypes: two D alleles (genotype DD), two I alleles (genotype II), and heterozygous allele (genotype DI). Genotype II was found in 65% of the patients with aneurysm and 12.5% of those without aneurysm (P < 0.01, odds ratio 13.0, 95% confidence intervals). CONCLUSION: Patients with Kawasaki disease and coronary aneurysm more often than expected had the genotype II suggesting that reactions induced by the type of ACE polymorphism predispose to coronary aneurysm formation. |
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Authors:
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K Takeuchi; K Yamamoto; S Kataoka; T Kakihara; A Tanaka; S Sato; M Uchiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatrics Volume: 156 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-03 Completed Date: 1997-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 266-8 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Niigata University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Child Child, Preschool Coronary Aneurysm / complications* Female Gene Frequency Humans Infant Japan / epidemiology Male Mucocutaneous Lymph Node Syndrome / epidemiology, genetics* Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* Sex Distribution |
| Chemical | |
Reg. No./Substance:
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EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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