Document Detail


High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells.
MedLine Citation:
PMID:  20960036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neurotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.
Authors:
Han Liu; Qingyong Ma; Junhui Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-20
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  347     ISSN:  1573-4919     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-03-28     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-101     Citation Subset:  IM    
Affiliation:
Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 227 West Yan-ta Road, Xi'an, 710061, China.
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MeSH Terms
Descriptor/Qualifier:
Cell Line, Tumor
Cell Proliferation / drug effects
Densitometry
Gene Expression Regulation, Neoplastic / drug effects
Glial Cell Line-Derived Neurotrophic Factor / genetics,  metabolism*
Glucose / pharmacology*
Humans
Pancreatic Neoplasms / genetics,  pathology*
Proto-Oncogene Proteins c-ret / genetics,  metabolism*
RNA, Messenger / genetics,  metabolism
Chemical
Reg. No./Substance:
0/GDNF protein, human; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/RNA, Messenger; 50-99-7/Glucose; EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human

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