| High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 19932004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Dietary fructose intake has increased considerably in recent decades and this has been paralleled by an increase in the incidence of insulin resistance, especially in children and adolescents. The impact of a high-fructose diet on the myocardium is not fully understood. The aims of this study were to characterize the murine metabolic and cardiac phenotypes associated with a high-fructose diet and to determine whether this diet imparts differential effects with age. METHODS: Juvenile (4 wk) and adult (14 wk) C57Bl/6 mice were fed a 60% fructose diet or isoenergetic control (starch) diet for 6 wk. RESULTS: At completion of the dietary intervention (at ages 10 and 20 wk), fructose-fed mice were normotensive; hyperinsulinemia and cardiac hypertrophy were not evident. Interestingly, fructose-fed mice exhibited lower blood glucose levels (10 wk: 4.81+/-0.28 versus 5.42+/-0.31 mmol/L; 20 wk: 4.88+/-0.30 versus 5.96+/-0.42 mmol/L, P<0.05) compared with controls. Nicotinamide adenosine dinucleotide phosphate-driven myocardial superoxide production was significantly increased in fructose-fed mice at both ages (by approximately 29% of control at 10 wk of age and 16% at 20 wk, P<0.01). No increase in aortic superoxide production was observed. Fructose feeding did not alter gene expression of the antioxidant thioredoxin-2, suggesting an imbalance between myocardial reactive oxygen species generation and antioxidant induction. CONCLUSION: These findings indicate that increased myocardial superoxide production may represent an early and primary cardiac pathologic response to the metabolic challenge of excess dietary fructose in juveniles and adults that can be detected in the absence of cardiac hypertrophy and hypertension. |
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Authors:
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Kimberley Mellor; Rebecca H Ritchie; Greta Meredith; Owen L Woodman; Margaret J Morris; Lea M D Delbridge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-20 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 26 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 842-8 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Blood Glucose / metabolism* Blood Pressure / drug effects Cardiomegaly Dietary Sucrose / administration & dosage* Fructose / pharmacology* Gene Expression / drug effects Heart / drug effects* Insulin / blood* Male Mice Mice, Inbred C57BL Myocardium / metabolism*, pathology NADP / metabolism Superoxides / metabolism* Thioredoxins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Sucrose; 11061-68-0/Insulin; 11062-77-4/Superoxides; 30237-26-4/Fructose; 52500-60-4/Thioredoxins; 53-59-8/NADP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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