| High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels. | |
| | |
MedLine Citation:
|
PMID: 20219526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Some studies have shown that short-term access to HFCS can cause increased body weight, but the findings are mixed. The current study examined both short- and long-term effects of HFCS on body weight, body fat, and circulating triglycerides. In Experiment 1, male Sprague-Dawley rats were maintained for short term (8 weeks) on (1) 12 h/day of 8% HFCS, (2) 12 h/day 10% sucrose, (3) 24 h/day HFCS, all with ad libitum rodent chow, or (4) ad libitum chow alone. Rats with 12-h access to HFCS gained significantly more body weight than animals given equal access to 10% sucrose, even though they consumed the same number of total calories, but fewer calories from HFCS than sucrose. In Experiment 2, the long-term effects of HFCS on body weight and obesogenic parameters, as well as gender differences, were explored. Over the course of 6 or 7 months, both male and female rats with access to HFCS gained significantly more body weight than control groups. This increase in body weight with HFCS was accompanied by an increase in adipose fat, notably in the abdominal region, and elevated circulating triglyceride levels. Translated to humans, these results suggest that excessive consumption of HFCS may contribute to the incidence of obesity. |
| | |
Authors:
|
Miriam E Bocarsly; Elyse S Powell; Nicole M Avena; Bartley G Hoebel |
Related Documents
:
|
11269866 - Oral colonization and cariogenicity of streptococcus gordonii in specific pathogen-free... 12728006 - Osmoregulation in an avian nectarivore, the whitebellied sunbird nectarinia talatala: r... 19902016 - The study on long-term toxicity of d-psicose in rats. 8163736 - Effect of frequent consumption of starchy food items on enamel and dentin demineralizat... 19588726 - High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. 12325116 - Digesta passage and fiber digestibility in captive white-faced sakis (pithecia pithecia). |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-26 |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 97 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-11 Completed Date: 2011-09-15 Revised Date: 2011-09-22 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 101-6 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Psychology, Princeton University, Princeton, NJ 08540, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
drug effects,
metabolism* Animals Body Weight / drug effects, physiology* Female Fructose / administration & dosage, toxicity* Male Obesity / chemically induced, metabolism* Rats Rats, Sprague-Dawley Sex Characteristics Time Factors Triglycerides / blood* Weight Gain / drug effects, physiology Zea mays* |
| Grant Support | |
ID/Acronym/Agency:
|
AA-12882/AA/NIAAA NIH HHS; DK-079793/DK/NIDDK NIH HHS; F32 DK079793-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Triglycerides; 30237-26-4/Fructose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ethanol-induced locomotor sensitization in DBA/2J mice is associated with alterations in GABA(A) sub...
Next Document: The influence of the long-term administration of Curcuma longa extract on learning and spatial memor...