Document Detail


High-frequency ventricular ectopy can increase sympathetic neural activity in humans.
MedLine Citation:
PMID:  20184979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sudden cardiac death is usually caused by ventricular arrhythmias and in many cases, is preceded by frequent ventricular ectopy. It is known that ectopic beats cause transient increases in sympathetic nerve activity (SNA). OBJECTIVE: Because high SNA is known to be arrhythmogenic, we hypothesized that high rates of ectopy increase SNA, thereby creating a milieu that favors development of ventricular tachycardia and/or fibrillation. METHODS: This study measured muscle SNA, coronary sinus catecholamine, and arterial pressure during graded rates of ventricular ectopy (from 4:1 to 1:1, sinus to ectopic beat ratio) in a total of 21 patients referred for electrophysiologic testing. RESULTS: Both muscle SNA and coronary sinus norepinephrine increased significantly with increased ectopy frequency (P < .05). Moreover, the change in muscle SNA correlated significantly with the change in coronary sinus norepinephrine levels (r = .72, P < .001). CONCLUSION: These data demonstrate that sympathoexcitation evoked by high rates of ventricular ectopy can contribute to a state of elevated SNA both in peripheral tissues and within the heart. This altered autonomic state may contribute to an increased susceptibility to life-threatening tachyarrhythmias in patients with high rates of ectopy.
Authors:
Michael L Smith; Mohamed H Hamdan; Stephen L Wasmund; Christina F Kneip; Jose A Joglar; Richard L Page
Related Documents :
20929559 - Changes in deceleration capacity of heart rate and heart rate variability induced by am...
8353919 - The ability of several short-term measures of rr variability to predict mortality after...
11485279 - Absence of slowest oscillations in short term heart rate variability of post-myocardial...
10190509 - Heart rate variability and occurrence of ventricular arrhythmias during balloon occlusi...
15870589 - Heart rate variability analysis in the assessment of autonomic function in heart failure.
10363869 - Cardiac sympathetic activity as measured by myocardial 123-i-metaiodobenzylguanidine up...
24507069 - Pain in the left ear as the presenting symptom of acute myocardial infarction in a rena...
22547149 - Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in ...
17574129 - 3d and 2d delayed-enhancement magnetic resonance imaging for detection of myocardial in...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-01-04
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  7     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-503     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, USA. msmith@hsc.unt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System Diseases / blood,  etiology*
Catecholamines / blood
Death, Sudden, Cardiac / etiology*
Female
Hemodynamics
Humans
Male
Middle Aged
Sympathetic Nervous System / physiopathology*
Ventricular Premature Complexes / blood,  complications*,  physiopathology
Young Adult
Grant Support
ID/Acronym/Agency:
HL-04996/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines
Comments/Corrections
Comment In:
Heart Rhythm. 2010 Apr;7(4):504-5   [PMID:  20189496 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Causes of ventricular oversensing in implantable cardioverter-defibrillators: implications for diagn...
Next Document:  Prediagnosis Food Patterns Are Associated with Length of Survival from Epithelial Ovarian Cancer.