Document Detail

High-frequency ventilation in lung edema: effects on gas exchange and perfusion.
MedLine Citation:
PMID:  6363368     Owner:  NLM     Status:  MEDLINE    
In six open-chest dogs, unilobar pulmonary edema was induced by injection of oleic acid into a lower lobe pulmonary arterial branch. Two hours later, intermittent positive-pressure ventilation (IPPV) and high-frequency oscillatory ventilation (HFOV) at matched mean alveolar pressures (MAP) were compared at 30-min intervals. The edematous lobar venous admixture (Qva/QT) increased by 0.14 (P less than 0.1) and its relative perfusion (QL/QT) decreased by 0.03. (P less than 0.1) during HFOV compared with IPPV. In another six dogs the MAP was increased by 1.5 cmH2O during HFOV; now the edematous lobar Qva/QT decreased by 0.15 (P less than 0.03) and QL/QT increased by 0.03 (P less than 0.03) during HFOV compared with IPPV. Greater MAP during HFOV also improved the edematous lobar ventilation (lobar venous PCO2) during HFOV compared with IPPV. Conceivably, the increase in MAP inflated collapsed, flooded regions, and thereby increased their O2 transfer, perfusion, and ventilation. Whole-lung Qva/QT was similar during IPPV and HFOV in both groups because of the opposing effects of lobar Qva/QT and QL/QT. We conclude that HFOV supports cardiovascular-respiratory function in open-chest unilobar pulmonary edema compared with IPPV at similar MAP; gas exchange and perfusion of edematous units may be sensitive to small changes in MAP, and we detected no intrinsic effects of HFOV on these variables. We speculate that similar beneficial effects in diffuse pulmonary edema may be effected by small variations in MAP during HFOV without the barotrauma side effects sometimes observed when MAP is increased during IPPV.
P H Breen; J Ali; L D Wood
Related Documents :
9710098 - Exogenous surfactant and positive end-expiratory pressure in the treatment of endotoxin...
12904188 - A lung recruitment maneuver immediately before rescue surfactant therapy does not affec...
23915548 - Metabolic and haemodynamic changes in the pathologic hypermobile spine.
20225818 - Forced and spontaneous imbibition of surfactant solution into an oil-wet capillary: the...
20012998 - Very preterm birth is a risk factor for increased systolic blood pressure at a young ad...
20852048 - 2,3',4,5'-tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  56     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-08     Completed Date:  1984-03-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Disease Models, Animal
Oleic Acids
Positive-Pressure Respiration
Pulmonary Edema / chemically induced,  physiopathology*
Pulmonary Gas Exchange*
Respiration, Artificial / methods*
Ventilation-Perfusion Ratio
Reg. No./Substance:
0/Oleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Threshold of airway response to inhaled methacholine in healthy men and women.
Next Document:  Plasma osmolality, volume, and renin activity at the "anaerobic threshold".