Document Detail

High frequency ventilation and afferent vagal activity.
MedLine Citation:
PMID:  3434737     Owner:  NLM     Status:  MEDLINE    
Recordings were made from pulmonary afferent fibres in the vagus nerves of anaesthetised dogs during conventional and high frequency ventilation. In single and multiple fibre preparations, the mean spike counts per minute at 14 breaths/minute were in the ranges 36.9-155.3 and 755-1921, respectively. These counts decreased by up to 61 and 44% respectively at 100 breaths/minute, and by 27-89% and 22-51% at 200 breaths/minute. At this frequency there was a further decrease of between 19 and 65% when the positive end expiratory pressure was removed. The findings of this study are intuitively acceptable, since pulmonary stretch receptor activity is proportional to tidal volume, and are in keeping with the clinical impression that high frequency ventilation per se does not eliminate respiratory drive.
A W Harrop-Griffiths; M K Chakrabarti; J G Whitwam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  42     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-29     Completed Date:  1988-02-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1162-70     Citation Subset:  AIM; IM    
Royal Postgraduate Medical School, Hammersmith Hospital, London.
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MeSH Terms
Blood Pressure
High-Frequency Ventilation*
Nerve Fibers / physiology*
Neurons, Afferent / physiology*
Vagus Nerve / physiology*

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