Document Detail

High-frequency ventilation for acute lung injury and ARDS.
MedLine Citation:
PMID:  10988205     Owner:  NLM     Status:  MEDLINE    
In patients with acute lung injury (ALI) and ARDS, conventional mechanical ventilation (CV) may cause additional lung injury from overdistention of the lung during inspiration, repeated opening and closing of small bronchioles and alveoli, or from excessive stress at the margins between aerated and atelectatic lung regions. Increasing evidence suggests that smaller tidal volumes (VTs) and higher end-expiratory lung volumes (EELVs) may be protective from these forms of ventilator-associated lung injury and may improve outcomes from ALI/ARDS. High-frequency ventilation (HFV)-based ventilatory strategies offer two potential advantages over CV for patients with ALI/ARDS. First, HFV uses very small VTs, allowing higher EELVs with less overdistention than is possible with CV. Second, despite the small VTs, high respiratory rates during HFV allow the maintenance of normal or near-normal PaCO2 levels. In this review, the use of HFV as a lung protective strategy for patients with ALI/ARDS is discussed.
J A Krishnan; R G Brower
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chest     Volume:  118     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-10-12     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-807     Citation Subset:  AIM; IM    
Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
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MeSH Terms
Expiratory Reserve Volume / physiology
High-Frequency Ventilation* / methods
Pulmonary Gas Exchange / physiology
Respiratory Care Units / methods
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*
Comment In:
Chest. 2001 Jun;119(6):1978-9   [PMID:  11399741 ]

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