Document Detail


High-frequency ultrasound for evaluation of intimal thickness.
MedLine Citation:
PMID:  19647399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The measurement of carotid intima-medial thickness is a well-validated measure of cardiovascular risk. Although atherosclerosis occurs in the intima, this arterial layer is not measured alone because of the limitation in ultrasound resolution with standard-frequency probes.
METHODS: We evaluated the feasibility of using a 55-MHz ultrasound system with high resolution to measure intima thickness in several vascular territories compared with a "standard" frequency probe.
RESULTS: The intima-medial thickness was measured in the brachial, radial, and tibial arteries in 10 healthy subjects and 5 subjects with peripheral arterial disease. The high-frequency ultrasound probe showed superior resolution compared with the standard-frequency probe, allowing for measurement of intima separately from media.
CONCLUSION: The intima can be measured independently of media with a high degree of reproducibility using a high-frequency probe. This technology may allow for early detection of cardiovascular risk and extend knowledge about the physiologic changes in early atherosclerotic development.
Authors:
Emile R Mohler; Alexandra A Sibley; Susan M Schultz; Lifeng Zhang; Chandra M Sehgal
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-31
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  22     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-04     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1129-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carotid Arteries / ultrasonography*
Echocardiography / instrumentation*
Equipment Design
Equipment Failure Analysis
Feasibility Studies
Female
Humans
Image Enhancement / instrumentation*
Male
Peripheral Vascular Diseases / ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Tunica Intima / ultrasonography*
Grant Support
ID/Acronym/Agency:
5K12HL83772-2/HL/NHLBI NIH HHS; K12 HL083772/HL/NHLBI NIH HHS; K12 HL083772-01A1/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Am Soc Echocardiogr. 2009 Oct;22(10):1134-6   [PMID:  19801302 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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