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High frequency ultrasonography but not 930nm-optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study.
MedLine Citation:
PMID:  24863700     Owner:  NLM     Status:  Publisher    
BACKGROUND: Early diagnosis and rapid surgical excision are essential for improving the prognosis of melanoma patients. Reflectance confocal microscopy has been validated as a feasible procedure for in vivo diagnosis of melanoma but cannot be used to measure tumour thickness. However, ultrasonography and optical coherence tomography may allow melanoma thickness to be measured in vivo.
OBJECTIVES: Primary: To validate the accuracy and reliability of high-frequency ultrasonography and optical coherence tomography for assessing melanoma thickness in vivo.
METHODS: We conducted a prospective study on 131 patients with at least one equivocal melanocytic lesion. Each lesion underwent optical coherence tomography and high-frequency ultrasonography assessment, followed by excision and pathological examination. Histopathology was considered as the gold standard for assessing melanoma thickness. Repeatability, inter- and intra-rater reproducibility and reliability were evaluated for each imaging procedure.
RESULTS: Ultrasonography showed a good level of agreement with histology (ICC: 0.807; [95% CI: 0 .703; 0.877]) and excellent inter-rater reproducibility (G=0.97), resulting in reliable in vivo assessment of melanoma thickness. 930nm-Optical coherence tomography showed a poor level of agreement with histopathology (ICC: 0.0; [95%CI: -0.2; 0.2]) and the inter-rater reproducibility was null (G=0.00).
CONCLUSION: HFUS is a reliable and reproducible non-invasive method for assessing melanoma thickness. Routine use of HFUS may allow single-step excision of equivocal melanocytic lesions, with surgical margins determined by in vivo assessment of tumour thickness. This article is protected by copyright. All rights reserved.
N Meyer; V Lauwers-Cances; S Lourari; J Laurent; M-P Konstantinou; J-M Lagarde; B Krief; H Batatia; L Lamant; C Paul
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-23
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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