Document Detail

High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease.
MedLine Citation:
PMID:  21296669     Owner:  NLM     Status:  Publisher    
Chronic high-frequency stimulation of the subthalamic nucleus (STN-HFS) efficiently alleviates motor symptoms of advanced Parkinson's disease (PD). Here, we looked for possible STN-HFS-induced changes on adult brain neurogenesis in the hippocampus and olfactory bulb that may be related to non-motor deficits associated to PD, such as mood disorders and olfaction deficits. Cell proliferation (Ki-67 immuno-positive-cells) and survival (bromodeoxyuridine (BrdU)-immuno-positive cells) were assessed in the subventricular zone-olfactory bulb continuum and the dentate gyrus of the hippocampus of hemiparkinsonian rats with or without continuous STN-HFS for 8 days. Dopamine lesion impaired cell proliferation and survival through different mechanisms, the effect on proliferation being correlated to the level of dopamine depletion whereas the effect on survival was not. Prolonged STN-HFS did not affect cell proliferation, but increased cell survival bilaterally. In these regions of constitutive neurogenesis, the percentage of new neuroblasts (BrdU-doublecortin-positive cells) was unchanged, suggesting that STN-HFS can lead to a net increase in newly formed neurons later on. STN-HFS also increased new cell survival in the striatum and promoted dopamine system recovery detected by tyrosine hydroxylase immunostaining. These data provide the first evidence that prolonged STN- HFS has a neurorestorative action and support the view that the action of this neurosurgical treatment can bypass the cortico-basal ganglia-thalamocortical loop circuits and largely impinge neuroplasticity and brain function.
Vitaly Khaindrava; Pascal Salin; Christophe Melon; Michael Ugrumov; Lydia Kerkerian-Le-Goff; Annie Daszuta
Related Documents :
16228979 - Flow cytometric analysis of tracheary element differentiation in zinnia elegans cells.
9025059 - Pluripotency and differentiation of embryonic stem cell lines from the medakafish (oryz...
3017799 - Differentiation of tera-2 human embryonal carcinoma cells into neurons and hcmv permiss...
8299879 - Mixed parenchymal-stromal populations of rat adrenocortical cells support the prolifera...
21278919 - Chicken hoxa3 gene: its expression pattern and role in branchial nerve precursor cell m...
19931509 - Mir-200a-mediated downregulation of zeb2 and ctnnb1 differentially inhibits nasopharyng...
7420049 - Control of active proton transport in turtle urinary bladder by cell ph.
4043279 - Properties of end-zone inhibition of hypercomplex cells in cat striate cortex.
16652189 - Knockdown of survivin gene by vector-based short hairpin rna technique induces apoptosi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-2
Journal Detail:
Title:  Neurobiology of disease     Volume:  -     ISSN:  1095-953X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
IC2N, IBDML, UMR6216 CNRS-Université de la Méditerranée, Marseille, France; Laboratory of Neurohistology, Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Autophagy failure in Alzheimer's disease--locating the primary defect.
Next Document:  Solution NMR structure and dynamics of human apo-S100A1 protein.