Document Detail


High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance.
MedLine Citation:
PMID:  18550758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the hypothesis that the clinical benefit exerted by STN HFS is accompanied by suppression of local beta activity. To this end, we explored the after effects of STN HFS on the oscillatory local field potential (LFP) activity recorded from the STN immediately after the cessation of HFS in 11 PD patients. Only patients that demonstrated a temporary persistence of clinical benefit after cessation of HFS were analyzed. STN HFS led to a significant reduction in STN LFP beta activity for 12 s after the end of stimulation and a decrease in motor cortical-STN coherence in the beta band over the same time period. The reduction in LFP beta activity correlated with the movement amplitude during a simple motor task, so that a smaller amount of beta activity was associated with better task performance. These features were absent when power in the 5-12 Hz frequency band was considered. Our findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological beta activity in PD.
Authors:
Andrea A Kühn; Florian Kempf; Christof Brücke; Louise Gaynor Doyle; Irene Martinez-Torres; Alek Pogosyan; Thomas Trottenberg; Andreas Kupsch; Gerd-Helge Schneider; Marwan I Hariz; Wim Vandenberghe; Bart Nuttin; Peter Brown
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  28     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-07-10     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6165-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Beta Rhythm / radiation effects*
Deep Brain Stimulation / methods*
Dose-Response Relationship, Drug
Female
Functional Laterality
Humans
Male
Middle Aged
Movement / physiology,  radiation effects*
Parkinson Disease / physiopathology*,  therapy*
Spectrum Analysis
Subthalamic Nucleus / physiology,  radiation effects*
Task Performance and Analysis
Time Factors
Grant Support
ID/Acronym/Agency:
G0400617//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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