| High frequency of serious side effects from meglumine antimoniate given without an upper limit dose for the treatment of visceral leishmaniasis in human immunodeficiency virus type-1-infected patients. | |
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MedLine Citation:
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PMID: 10586909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organic pentavalent antimonials are one of the mainstays of treatment for visceral leishmaniasis (VL). Few data are available on the toxicity and efficacy of these drugs at the dosing schedule recommended by the Centers for Disease Control and Prevention (CDC) (Atlanta, GA). We analyzed 25 VL episodes in human immunodeficiency virus (HIV)-infected patients who were treated with meglumine antimoniate (MA) at the CDC-recommended dose in southern Spain. Adverse effects were observed in 14 (56%) VL episodes. In 7 (28%), treatment with MA was permanently discontinued due to serious adverse effects that included acute pancreatitis, acute renal failure, and leukopenia. Three (12%) patients died during therapy due to severe acute pancreatitis attributable to MA. The dosing regimen of MA currently recommended for treating VL is associated with a high rate of serious side effects in HIV-1-infected patients. |
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Authors:
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J Delgado; J Macías; J A Pineda; J E Corzo; M P González-Moreno; R de la Rosa; A Sánchez-Quijano; M Leal; E Lissen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 61 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-21 Completed Date: 1999-12-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 766-9 Citation Subset: AIM; IM; X |
Affiliation:
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Departamento de Medicina Interna, Hospital Universitario Virgen del Rocío, Seville, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amylases / blood Animals Antimony / administration & dosage, adverse effects, therapeutic use Antiprotozoal Agents / administration & dosage, adverse effects*, therapeutic use Bone Marrow / parasitology Creatinine / blood Female HIV Infections / complications* HIV-1* Humans Leishmania infantum / drug effects* Leishmaniasis, Visceral / complications, drug therapy* Leukocyte Count Male Meglumine / administration & dosage, adverse effects*, therapeutic use Organometallic Compounds / administration & dosage, adverse effects*, therapeutic use Pancreatitis / chemically induced Recurrence Retrospective Studies Vomiting |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 0/Organometallic Compounds; 133-51-7/meglumine antimoniate; 60-27-5/Creatinine; 6284-40-8/Meglumine; 7440-36-0/Antimony; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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