Document Detail


High-frequency oscillatory ventilation with partial liquid ventilation in a model of acute respiratory failure.
MedLine Citation:
PMID:  9034268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether there is an improvement in oxygenation when partial liquid ventilation and high-frequency oscillatory ventilation are combined in the treatment of acute lung injury, compared with high-frequency oscillatory ventilation alone. DESIGN: Controlled animal trial. SETTING: Research laboratory in a university setting. SUBJECTS: Ten 3-kg piglets. INTERVENTIONS: Anesthetized piglets underwent high-frequency oscillatory ventilation, with mean airway pressure of 20 cm H2O, before induction of acute lung injury with repeated saline lavage. When PaO2 values were < 100 torr (< 13.3 kPa), five animals were randomized to receive escalating doses (3, 15, and 30 mL/kg) of perflubron at 60-min intervals. The other five animals remained on high-frequency oscillatory ventilation only. Sham dosing was performed at 60-min intervals in these animals. Arterial blood gases were obtained in both groups at baseline, after injury, and after perflubron and sham doses. MEASUREMENTS AND MAIN RESULTS: Statistically significant improvements in oxygenation were demonstrated in animals that received 3 mL/kg of perflubron with high-frequency oscillatory ventilation compared with animals receiving high-frequency oscillatory ventilation alone (253 +/- 161 vs. 90 +/- 30 torr [33.65 +/- 21.46 vs. 12.0 +/- 4.0 kPa], p < .05). Improvements in oxygenation with additional administration of perflubron were not greater than the improvements seen in the high-frequency oscillatory ventilation-only group. PaCO2 and pH were similar in both groups at all times. No hemodynamic compromise occurred in either group of animals. CONCLUSIONS: The combination of low-dose perflubron with high-frequency oscillatory ventilation leads to more rapid improvement in arterial oxygenation than high-frequency oscillatory ventilation alone, in a piglet model of acute lung injury. Although the group receiving high-frequency oscillatory ventilation alone eventually achieved PaO2 values that were equivalent to the group receiving high-frequency ventilation and perflubron, the combination of perflubron with high-frequency oscillatory ventilation may permit effective oxygenation and ventilation at lower mean airway pressures by facilitating alveolar expansion and decreasing intrapulmonary shunt.
Authors:
H P Baden; J D Mellema; S L Bratton; P P O'Rourke; J C Jackson
Related Documents :
16798558 - High frequency oscillation and liquid ventilation.
22924758 - Balance and agility training does not always decrease lower limb injury risks: a cluste...
17524058 - Agonal sequences in a filmed suicidal hanging: analysis of respiratory and movement res...
4014868 - Do prostaglandins have a role in breathlessness?
6542858 - Dissociation between vo2max and ventilatory threshold responses to endurance training.
10609188 - Moderate-high intensity exercise training after myocardial infarction: effect on left v...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  25     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, University of Washington School of Medicine and Children's Hospital, Seattle, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anti-Obesity Agents / therapeutic use*
Blood Gas Analysis
Fluorocarbons / therapeutic use*
High-Frequency Ventilation*
Models, Biological
Respiratory Insufficiency / therapy*
Swine
Chemical
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Fluorocarbons; 423-55-2/perflubron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enteral administration of ornithine alpha-ketoglutarate or arginine alpha-ketoglutarate: a comparati...
Next Document:  Inotropes inhibit endothelial cell surface adhesion molecules induced by interleukin-1beta.