Document Detail


High-frequency oscillatory ventilation is not associated with increased risk of neuropathology compared with positive pressure ventilation: a preterm primate model.
MedLine Citation:
PMID:  19687780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High-frequency oscillatory ventilation (HFOV) may improve pulmonary outcome in very preterm infants, but the effects on the brain are largely unknown. We hypothesized that early prolonged HFOV compared with low volume positive pressure ventilation (LV-PPV) would not increase the risk of delayed brain growth or injury in a primate model of neonatal chronic lung disease. Baboons were delivered at 127 +/- 1 d gestation (dg; term approximately 185 dg), ventilated for 22-29 d with either LV-PPV (n = 6) or HFOV (n = 5). Gestational controls were delivered at 153 dg (n = 4). Brains were assessed using quantitative histology. Body, brain, and cerebellar weights were lower in both groups of prematurely delivered animals compared with controls; the brain to body weight ratio was higher in HFOV compared with LV-PPV, and the surface folding index was lower in the LV-PPV compared with controls. In both ventilated groups compared with controls, there was an increase in astrocytes and microglia and a decrease in oligodendrocytes (p < 0.05) in the forebrain and a decrease in cerebellar granule cell proliferation (p < 0.01); there was no difference between ventilated groups. LV-PPV and HFOV ventilation in prematurely delivered animals is associated with decreased brain growth and an increase in subtle neuropathologies; HFOV may minimize adverse effects on brain growth.
Authors:
Michelle Loeliger; Terrie E Inder; Amy Shields; Penelope Dalitz; Sarah Cain; Bradley Yoder; Sandra M Rees
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-01-12     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Affiliation:
Anatomy and Cell Biology, University of Melbourne, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / pathology
Body Weight
Brain / growth & development,  pathology
Brain Diseases / etiology,  pathology*
Cell Proliferation
Disease Models, Animal
Female
High-Frequency Ventilation / methods*
Lung Diseases / pathology*
Male
Necrosis
Oligodendroglia / metabolism
Papio
Primates
Risk
Grant Support
ID/Acronym/Agency:
HL52636/HL/NHLBI NIH HHS; HL52646/HL/NHLBI NIH HHS; R01 HL074942/HL/NHLBI NIH HHS; R01 HL074942-01A1/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets...
Next Document:  ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts...