Document Detail

High-frequency oscillatory ventilation for infants and children with adult respiratory distress syndrome.
MedLine Citation:
PMID:  9151467     Owner:  NLM     Status:  MEDLINE    
Two infants and two children suffered from severe hypoxemia, presenting as a ratio of arterial to alveolar PaO2 < 0.1, persisting for more than 3 hours in spite of high settings on conventional mechanical ventilator. Adult respiratory distress syndrome was diagnosed with the support of bilateral diffuse haziness on chest radiographs. High-frequency oscillatory ventilation with high-lung-volume strategy resulted in prompt decrease in oxygenation index and increase in ratio of arterial to alveolar P O2 in three (75%) of the 4 patients within 6 hours. After a mean duration of 96 hours, high-frequency oscillatory ventilation could be weaned off and conventional ventilation could be resumed at lower mean airway pressure in 3 patients. They continued to improve and finally recovered. The other one showed initially steady improvement on high-frequency oscillatory ventilation for 20 hours, but ultimately died of unresolved cytomegalovirus pneumonitis and intractable pulmonary hemorrhage. There were 2 episodes of pneumothorax developing during high-frequency oscillatory ventilation. After decreasing mean airway pressure and amplitude, the airleak resolved with chest tube insertion. We conclude that high-frequency oscillatory ventilation with high-lung-volume strategy may be an effective rescue therapy to relieve profound hypoxemia in infants and children with adult respiratory distress syndrome.
J R Tang; K I Yau; H H Shih
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui     Volume:  38     ISSN:  0001-6578     ISO Abbreviation:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  16210470R     Medline TA:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
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MeSH Terms
Anoxia / complications,  therapy
Child, Preschool
High-Frequency Ventilation / methods*
Infant, Newborn
Oxygen / blood
Partial Pressure
Respiratory Distress Syndrome, Adult / complications,  therapy*
Time Factors
Reg. No./Substance:

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